文献类型：期刊文献

英文题名：The crosstalk network of non-coding RNAs: Emerging opportunities for the clinical application of osteoporosis

作者：Yan, Chunlu[1];Wan, Qiao[2];Fang, Zeling[2];Sui, Chuangwei[3];Xiao, Xiaolong[2];Yang, Fan[2];Di, Baoshan[4];Li, Yajun[5];Yu, Juan[6];Zhao, Yana[7];Liu, Guoliang[8];Zhou, Yibo[9];Li, Wei[9];An, Fangyu[10]

第一作者：颜春鲁

通信作者：An, FY[1];Di, BS[2]

机构：[1]Gansu Univ Chinese Med, Natl Inst Dunhuang Med, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Sch Trad Chinese & Werstern Med, Lanzhou 730000, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Sch Basic Med, Lanzhou 730000, Gansu, Peoples R China;[4]Longgang Cent Hosp Shenzhen, Dept Orthoped Trauma, Shenzhen 518000, Guangdong, Peoples R China;[5]Gansu Univ Chinese Med, Clin Coll Chinese Med, Lanzhou 730000, Gansu, Peoples R China;[6]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou 730000, Gansu, Peoples R China;[7]Tianshui City Hlth Sch, Dept Basic Teaching & Res Sect, Tianshui 741000, Gansu, Peoples R China;[8]Dingxi Tradit Chinese Med Hosp, Orthoped, Dingxi 743000, Gansu, Peoples R China;[9]Longgang Cent Hosp Shenzhen, Dept Emergency Med, Shenzhen 518000, Guangdong, Peoples R China;[10]Gansu Univ Chinese Med, Teaching Expt Training Ctr, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Teaching Expt Training Ctr, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Longgang Cent Hosp Shenzhen, Dept Orthoped Trauma & Emergency Med, Shenzhen 518000, Guangdong, Peoples R China.|[10735]甘肃中医药大学;

年份：2026

卷号：17

起止页码：90

外文期刊名：NON-CODING RNA RESEARCH

收录：Scopus(收录号：2-s2.0-105024996217);WOS:【ESCI(收录号:WOS:001669059700001)】；

基金：This work was financially supported by the National Natural Science Foundation of China (Grant No. 82560967) , Internal fund projects of Longgang Central Hospital of Shenzhen (Grant No. YN2025B009) , Gansu Joint Research Fund Project (Grant No. 24JRRA879) , Gansu Natural Science Foundation (Grant No. 24JRRA1018) , the Scientific Research Program of Gansu Chinese Medicine Bure (Grant No. GZKG-2024-88) , Dingxi Technology Plan Project (Grant No. DX2024BY017) , and Teaching Reform Research Project of Gansu Higher Education (Grant No. GJJGB228) .

语种：英文

外文关键词：Osteoporosis; ncRNA; Extracellular vesicles; Network regulation; Clinical application

摘要：Current methods for testing bone density lack the capability to detect patients with early bone loss, and existing osteoporosis therapies have limitations in their efficacy and safety. Therefore, the development of more precise and convenient diagnostic technologies and novel treatments is of paramount importance. Extracellular vesicle (EV)-mediated non-coding RNA (ncRNA) interaction networks enable both the detection of early bone loss and targeted therapy for enhanced treatment outcomes. In this review, we highlight the utility of EVs for carrying various ncRNAs (e.g., miRNAs, lncRNAs, and circRNAs) and thereby forming a complex regulatory network amongst bone-related cells such as osteoblasts and osteoclasts. The mechanisms through which EVs regulate bone cells and their potential for clinical translation are described in detail. Although the EV-mediated ncRNA network holds great promise for the precise diagnosis and targeted treatment of osteoporosis, rigorous large-scale studies are still required to address challenges related to its specificity and clinical application.