文献类型：期刊文献

中文题名：柴胡桂枝干姜汤及其单味药有效成分治疗慢性胆囊炎消化不良的研究进展

英文题名：Chaihu Guizhi Ganjiangtang and Its Single Active Ingredient in Treatment of Dyspepsia Caused by Chronic Cholecystitis:A Review

作者：杨文文[1];卢雨蓓[2];陈琳[1];张晶[3];高颖[1];张亚娟[1];李小艳[1];杨建飞[1];石小丽[1];蔺环环[1]

第一作者：杨文文

机构：[1]甘肃中医药大学中医临床学院,兰州730030;[2]甘肃省中医院脾胃病诊疗中心,兰州730050;[3]甘肃中医药大学附属医院,兰州730030

第一机构：甘肃中医药大学中医临床学院

年份：2026

卷号：32

期号：4

起止页码：289

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：;北大核心:【北大核心2023】；

基金：国家中医药管理局项目(3016170201);甘肃省自然科学基金项目(23JRRA1677);第五批全国中医临床优秀人才研修项目(国中医药人教函[2022:1号);国家中医药管理局2022年度中医药古籍文献和特色技术传承专项(GZY-KJS-2022-038)。

语种：中文

中文关键词：柴胡桂枝干姜汤;有效成分;慢性胆囊炎;消化不良;综述

外文关键词：Chaihu Guizhi Ganjiangtang;active ingredients;chronic cholecystitis;dyspepsia;review

摘要：柴胡桂枝干姜汤首载于《伤寒论》,处方由柴胡、黄芩、桂枝、干姜、栝篓根、牡蛎、甘草7味组成,具有疏利少阳、暖脾生津之效,临床多用于治疗慢性胆囊炎(CC)、肠易激综合征、非酒精性脂肪肝等多种消化道疾病。CC消化不良是由CC所导致的一组临床症候,包括腹痛、食欲欠佳、餐后饱胀、厌油腻、便溏、口苦等多种消化道症状,属于胆源性消化不良(BD)的一种,现代医学主要有内科和外科治疗,内科主要以针对CC此原发病的消炎、利胆溶石、解痉止痛治疗及针对消化不良症状为主的促进消化治疗,短期疗效尚可,但存在作用单一、复发率高、依存性欠佳等问题。外科手术虽能根治胆囊炎症的情况,但随之出现腹痛、腹泻、消化不良等不良事件的发生率会上升。现代临床证实柴胡桂枝干姜汤可显著改善CC患者腹痛、消化不良等症状,药理学研究发现柴胡桂枝干姜汤主要有柴胡皂苷、黄芩苷、桂皮醛、姜酚、姜辣素、天花粉多糖、牡蛎多糖、甘草总黄酮等成分,可通过抑制炎症反应、改善胆囊收缩功能及胃肠动力、调节胆汁酸(BA)-肠道菌群轴、调节血脂、调节脑-肠轴等多种机制、多靶点改善CC消化不良症状。该文通过回顾以往文献,对柴胡桂枝干姜汤及单味药主要成分治疗CC消化不良及CC消化不良机制的研究进展进行综述,并针对目前研究提出不足与改进策略,以期为进一步研究柴胡桂枝干姜汤治疗CC消化不良提供参考依据。
Chaihu Guizhi Ganjiangtang was first recorded in the Treatise on Cold Damage(Shang Han Lun).This prescription is composed of Bupleuri Radix,Scutellariae Radix,Cinnamomi Ramulus,Zingiberis Rhizoma,Trichosanthis Radix,Ostreae Concha,and Glycyrrhizae Radix et Rhizoma.It has the effects of soothing Lesser Yang,warming the spleen,and stimulating the generation of body fluid.It is mainly used to treat digestive tract diseases such as chronic cholecystitis(CC),irritable bowel syndrome,and non-alcoholic fatty liver disease.Dyspepsia caused by CC presents a variety of gastrointestinal symptoms such as abdominal pain,poor appetite,postprandial fullness,aversion to greasy food,soft stool,and bitter mouth,being a type of biliary dyspepsia.In modern medicine,dyspepsia caused by CC is mainly managed by medical treatment and surgical treatment.Internal medicine mainly focuses on reducing inflammation,promoting the function of gallbladder,resolving stones,alleviating spasms,and relieving the pain for CC,demonstrating definite short-term efficacy but suffering from single effects,high recurrence rate,and poor compliance.Although surgical treatment can cure cholecystitis,it is accompanied by the increased incidence of adverse events such as abdominal pain,diarrhea,and dyspepsia.Modern clinical studies have confirmed that Chaihu Guizhi Ganjiangtang can significantly alleviate the symptoms such as abdominal pain and dyspepsia of CC patients.Pharmacological studies have found that Chaihu Guizhi Ganjiangtang mainly contains active ingredients such as Bupleuri Radix saponins,baicalin,cinnamaldehyde,gingerol,Trichosanthis Radix polysaccharide,Ostreae Concha polysaccharide,and Glycyrrhizae Radix et Rhizoma total flavonoids.Chaihu Guizhi Ganjiangtang can ameliorate the symptoms of dyspepsia caused by CC by inhibiting inflammatory responses,improving gallbladder contraction and gastrointestinal motility,regulating the bile acidintestinal flora axis and the brain-gut axis,and modulating blood lipids through multiple targets.By reviewing the previous literature,this article summarizes the research progress in the treatment of dyspepsia caused by CC with Chaihu Guizhi Ganjiangtang and its main active ingredients as well as the pathogenesis of this disease and puts forward the shortcomings and improvement strategies for the current research.The review aims to provide a reference for the further research on Chaihu Guizhi Ganjiangtang in the treatment of dyspepsia caused by CC.