文献类型：期刊文献

中文题名：水通道蛋白与腹泻型肠易激综合征的相关性及中医药调控机制

英文题名：The correlation between aquaporin and diarrhea-type irritable bowel syndrome and the regulation mechanism of traditional Chinese medicine

作者：苏海霞[1];付兆媛[2];高永泽[1];尉戎戎[1];钟建春[1]

第一作者：苏海霞

机构：[1]甘肃中医药大学,兰州730000;[2]甘肃中医药大学附属医院消化科,兰州730000

第一机构：甘肃中医药大学

年份：2022

卷号：42

期号：8

起止页码：1545

中文期刊名：生命的化学

外文期刊名：Chemistry of Life

收录：CSTPCD

基金：甘肃省兰州市城关区科技计划项目(2021JSCX0008);甘肃中医药大学附属医院院内创新基金项目(gzfy-2020-11);甘肃省中西医结合肿瘤临床医学研究中心开放基金项目(zlzx2021-4);甘肃省教育科技创新项目(2022QB-092)。

语种：中文

中文关键词：水通道蛋白;腹泻型肠易激综合征;中医药;血管活性肠肽;cAMP-PKA信号通路;NF-κB信号通路;Na~+-K~+-ATP酶;微小RNA;

外文关键词：aquaporin;diarrhea-type irritable bowel syndrome;traditional Chinese medicine;vasoactive intestinal peptide;cAMP-PKA signaling pathway;NF-κB signaling pathway;Na+-K+-ATPase;miRNA;

摘要：腹泻型肠易激综合征在临床上经久难愈,是一种生理-心理-病理相关的疾病。水通道蛋白是介导水液跨膜转运的重要因子,主要通过调控腹泻型肠易激综合征患者的肠道内环境水液代谢、黏液合成和分泌等来改善症状。同时,水通道蛋白在维持肠道细胞内外环境稳态及调控肠神经功能中具有重要作用。近年来关于中医药调控水通道蛋白治疗腹泻型肠易激综合征的机制研究越来越多,同时作为治疗腹泻型肠易激综合征的新靶点,中医药对其的干预研究将有重要价值。基于此,笔者将中医药、水通道蛋白、腹泻型肠易激综合征三者联系起来,初步阐述中医药调控水通道蛋白治疗腹泻型肠易激综合征的机制研究进展,以期为临床工作者对于腹泻型肠易激综合征患者的靶向治疗及预后提供新的探索方向。
Diarrhea irritable bowel syndrome is a physiologically,psychologically and pathologically related disease that is difficult to cure in clinic.Aquaporin is an important factor that mediates the transmembrane transport of water.It can improve symptoms mainly by regulating the water metabolism,mucus synthesis and secretion in the intestinal environment of patients with diarrhea type irritable bowel syndrome.At the same time,it plays an important role in maintaining the homeostasis of intestinal cells and regulating intestinal nerve function.In recent years,there are more and more studies on the mechanism of traditional Chinese medicine regulating aquaporin in the treatment of diarrhea type irritable bowel syndrome.At the same time,as a new target for the treatment of diarrhea type irritable bowel syndrome,the intervention research of traditional Chinese medicine will be of great value.Based on this,the author links traditional Chinese medicine,aquaporin and diarrhea type irritable bowel syndrome,and preliminarily expounds the research progress of the mechanism of traditional Chinese medicine regulating aquaporin in the treatment of diarrhea type irritable bowel syndrome,in order to provide a new exploration direction for clinical workers for the targeted treatment and prognosis of patients with diarrhea type irritable bowel syndrome.