文献类型：期刊文献

中文题名：针刺对创伤后应激障碍模型大鼠海马CA1和CA3区神经电生理活动的影响

英文题名：Effects of acupuncture on neuro-electrophysiological activities in hippocampal CA1 and CA3 areas of rats with post-traumatic stress disorder

作者：Zhao Zhong-ting[1,2];Zhao Yi-kun[1];Zhu Tian-tian[1];Xing Jia-ming[3];Bu Xiao-mei[1];Zhang Yan-feng[1];Yan Xing-ke[1,2]

第一作者：赵中亭

通信作者：Yan, XK[1];Yan, XK[2]

机构：[1]Gansu Univ Chinese Med, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Postdoctoral Res Stn Tradit Chinese Med, Lanzhou 730000, Gansu, Peoples R China;[3]Gansu Prov Hosp Tradit Chinese Med, Lanzhou 730050, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Postdoctoral Res Stn Tradit Chinese Med, Lanzhou 730000, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2019

卷号：17

期号：2

起止页码：67

外文期刊名：JOURNAL OF ACUPUNCTURE AND TUINA SCIENCE

收录：Scopus(收录号：2-s2.0-85064917468);WOS:【ESCI(收录号:WOS:000465602200001)】；

基金：This work was supported by No. 62 General Project of China Postdoctoral Science Foundation (62, No. 2017M623269); 2014 Regional Science Fund of National Natural Science Foundation of China (2014, No. 81460744); 2013 Natural Science Foundation of Gansu Province (2013, No. 1308RJZA150).

语种：中文

外文关键词：Acupuncture Therapy; Point; Baihui (GV 20); Point; Neiguan (PC 6); Point; Shenmen (HT 7); Point; Taichong (LR 3); Stress Disorders; Post-traumatic; Electrophysiology; Rats

摘要：ObjectiveTo observe the effects of acupuncture on the characteristics of neuro-electrophysiological activity in hippocampal CA1 and CA3 areas of rats with post-traumatic stress disorder (PTSD).MethodsFifty Sprague-Dawley (SD) rats were randomly divided into a blank group, a model group, a grasping group, a Western medicine group and an acupuncture group, with 10 rats in each group. Except for the blank group, rats in the other 4 groups all received the combined stress modeling method. Rats in the Western medicine group were intragastrically administrated with paroxetine hydrochloride, those in the acupuncture group received acupuncture intervention, those in the grasping group received grasping fixation, and those in the model group and the blank group did not receive any interventions. After 14 d of intervention, the interspike interval (ISI) and power spectral densities (PSD) were analyzed and mapped by in vivo multiple channels to record the neuron clusters discharge in the hippocampal CA1 and CA3 areas.ResultsCompared with the blank group, ISI was prolonged in the CA1 and CA3 areas of the model group and the grasping group, and the concentrated PSD distribution area moved down (P<0.05 or P<0.01). Compared with the grasping group, the ISI of the CA1 and CA3 areas in the Western medicine group and the acupuncture group was shortened, and the concentrated PSD distribution area moved up (P<0.05 or P<0.01). The ISI and PSD distributions in the CA1 and CA3 areas of the acupuncture group were not statistically different from those in the Western medicine group (both P>0.05).ConclusionBoth acupuncture and paroxetine hydrochloride can significantly regulate the neuro-electrophysiology activity of hippocampal CA1 and CA3 areas in PTSD rats, which may be one of the mechanisms of acupuncture intervention to promote PTSD recovery.