文献类型：期刊文献

英文题名：Natural products: promising therapeutics for targeting regulatory immune cells in the tumor microenvironment

作者：Song, Peng[1,2];Song, Fei[1,2];Shao, Tingting[1,2];Wang, Pengjuan[1,2];Li, Rongkun[1,2];Chen, Zhe-Sheng[3];Zhang, Zhaofang[1,2];Xue, Guozhong[1,2]

第一作者：宋鹏

通信作者：Li, RK[1];Zhang, ZF[1];Xue, GZ[1];Li, RK[2];Zhang, ZF[2];Xue, GZ[2]

机构：[1]Gansu Univ Chinese Med, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou, Peoples R China;[3]St Johns Univ, Coll Pharm & Hlth Sci, Queens, NY USA

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Lanzhou, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2024

卷号：15

外文期刊名：FRONTIERS IN PHARMACOLOGY

收录：;Scopus(收录号：2-s2.0-85211113850);WOS:【SCI-EXPANDED(收录号:WOS:001363201000001)】；

基金：The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Natural Science Foundation of China (82260859 and 81803779), the Gansu Province Science Foundation for Distinguished Young Scholars (20JR10RA348), Longyuan Innovation and Entrepreneurship Team Project of Gansu Province, Longyuan Talent Project in Gansu Province, Natural Science Foundation of Gansu Province (22JR5RA611 and 22JR11RA125), and Traditional Chinese Medicine Scientific Research Project in Gansu Province in 2020 (GZKP-2020-32).

语种：英文

外文关键词：regulatory immune cells; natural products; polysaccharides; polyphenols; tumor therapy

摘要：Regulatory immune cells regulate immune responses through various mechanisms, affecting the occurrence, development, and therapeutic effects of tumors. In this article, we reviewed the important roles of regulatory immune cells, such as regulatory T cells (Tregs), regulatory B cells (Bregs), myeloid-derived suppressor cells (MDSCs), regulatory dendritic cells (DCregs), and tumor-associated macrophages (TAMs), in the tumor microenvironment (TME). The immunomodulatory effects of natural products, such as polysaccharides, polyphenols, glycosides, alkaloids, terpenoids, quinones, and other compounds, which affect the functions of regulatory immune cells through molecular signaling pathways, thereby enhancing the potential of the antitumor immune response, are discussed. These findings provide new ideas and possibilities for the application of natural products in tumor treatment, which can help enhance the effectiveness of tumor treatment and improve patient prognosis.