文献类型：期刊文献

中文题名：中药重金属生物可给性与转移率研究进展

英文题名：Research Progress in Bioaccessibility and Transfer Rates of Heavy Metals in TCM

作者：周德来[1];马春旭[1];姚晓玲[1];赵鲲鹏[2];李运[3];杨扶德[1];冯金梁[4]

第一作者：周德来

机构：[1]甘肃中医药大学药学院,甘肃兰州730000;[2]甘肃中医药大学中医临床学院,甘肃兰州730000;[3]兰州市食品药品检测检验研究院,甘肃兰州730000;[4]甘肃康乐药业有限责任公司,甘肃兰州730300

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

年份：2023

卷号：30

期号：1

起止页码：165

中文期刊名：中国中医药信息杂志

外文期刊名：Chinese Journal of Information on Traditional Chinese Medicine

收录：CSTPCD;;CSCD:【CSCD_E2023_2024】；

基金：甘肃高等学校产业支撑计划项目(2021CYZC-40);甘肃省科技小巨人企业培育计划项目(17CXIJA084);甘肃省委组织部人才发展专项资金项目(2018年);兰州市人才创新创业科技计划项目(2017-RC-112)。

语种：中文

中文关键词：中药;重金属;生物可给性;转移率;健康风险;综述

外文关键词：TCM;heavy metals;bioaccessibility;transfer rates;health risk;review

摘要：由于重金属对人体健康威胁受到高度关注,对中药所含重金属的暴露风险进行合理评估已成为研究重点。中药在体外提取及体内消化过程中,重金属元素从药材转移至提取液及消化液中的效率常利用转移率与生物可给性的概念进行表述,因此在重金属暴露评估中引入转移率、生物可给性作为校正因子对实现暴露风险的精准评估具有重要意义。本文归纳总结中药材重金属污染现状,结合中药实际应用方式,就转移率与生物可给性的相互关系、生物可给性的影响因素及其在风险评估中的具体应用等方面进行梳理,为中药所含重金属的风险控制及质量评价体系建立提供依据。
Due to the high degree of attention paid to the threat of heavy metals to human health,the reasonable assessment of the exposure risk of heavy metals contained in TCM has become the focus of research.In the process of extraction in vitro and digestion in vivo,the efficiency of heavy metal elements transferred from medicinal materials to extract and digestive juice is often expressed by the concepts of transfer rate and bioaccessibility.Therefore,the introduction of transfer rate and bioaccessibility as correction factors in heavy metal exposure assessment plays an important role in the accurate assessment of exposure risk.This article summarized the present situation of heavy metal pollution in TCM,combined with the practical application mode of TCM,and combed the relationship between transfer rate and bioaccessibility,the influencing factors of bioaccessibility and its specific application in risk assessment,so as to provide the basis for the risk control and establishment of quality evaluation system of heavy metals contained in TCM.