文献类型：期刊文献

中文题名：吴茱萸挥发油、芥子油及大黄总蒽醌对芍药苷体外经皮渗透的影响

英文题名：Effects of Volatile Oil of Fruetus Evodia, Mustard Oil and Total Anthraquinone in Rheum on Percutaneous Absorption of Paeoniflorin in Vitro

作者：闰治攀[1];李芸[1];魏舒畅[1];刘永琦[1]

第一作者：闰治攀

机构：[1]甘肃中医学院,甘肃省高校中藏药化学与质量研究省级重点实验室,甘肃兰州730000

第一机构：甘肃中医药大学科研实验中心（甘肃省中医药标准化技术委员会秘书处）

年份：2014

卷号：21

期号：1

起止页码：79

中文期刊名：中国中医药信息杂志

外文期刊名：Chinese Journal of Information on Traditional Chinese Medicine

收录：CSTPCD;;CSCD:【CSCD2013_2014】；

基金：兰州I市科技局项目（2009-2-11）

语种：中文

中文关键词：芍药苷;促渗剂;吴菜萸挥发油;芥子油;大黄总蒽醌

外文关键词：paeoniflorin; penetration enhancers, volatile oil of Fructus Evodia, mustard oil;total anthraquinone of Rheum

摘要：目的：考察吴茱萸挥发油、芥子油、大黄总蒽醌作为促渗剂对芍药苷经皮渗透的影响。方法采用YB-P6型智能透皮试验仪,以小鼠离体腹部皮肤为渗透屏障,采用高效液相色谱法对芍药苷含量进行测定,考察吴茱萸挥发油、芥子油、大黄总蒽醌3种促渗剂在12 h内对芍药苷累积渗透量、透皮吸收速率、透皮时滞等体外透皮吸收动力学参数的影响。结果吴茱萸挥发油、芥子油、大黄总蒽醌的渗透速率分别为8.1886、3.4117、1.2303 g/（cm2？h）,增渗倍数分别为22.6、9.40、3.40,透皮时滞分别为0.93、0.51、0.83 h。结论3种天然透皮促渗剂均能明显促进芍药苷的透皮吸收,为其作为透皮促渗剂提供了参考依据。
Objective To investigate the effects of volatile oil of Fructus Evodia, mustar d oil and total anthraquinone in Rheum on the transcutaneous permeability of paeoniflorin. Methods Using intelligent transdermal diffusion cell and excised mice skin in vitro as transdermal barrier, the kinetics parameters such as cumulative permeation quantity, permeation rate and permeation lagged time of the three kinds of penetration enhancers on paeoniflorin were determined by HPLC in 12 hours. Results The penetration rate of volatile oil of Fructus Evodia, mustard oil and total anthraquinone in Rheum were 8.188 6, 3.411 7, 1.230 3 μg/（cm2？h）, respectively, the enhancement ratios were 22.6, 9.40, 3.40, respectively, and the permeation lagged times were 0.93, 0.51, 0.83 h, respectively. Conclusion Three penetration enhancers all can enhance previously percutaneous absorption of paeoniflorin, which provides reference for the selection of the penetration enhancers of transdermal delivery.