文献类型：期刊文献

中文题名：ABC转运蛋白诱导卵巢癌化疗药物多药耐药的研究进展

英文题名：Research progress of multidrug resistance induced by ABC transporter in ovarian cancer

作者：张亚男[1];胡水平[1];刘玲[2];贾泽南[2];刘志杰[2]

第一作者：张亚男

机构：[1]甘肃中医药大学临床医学院,甘肃兰州730000;[2]解放军联勤保障部队第940医院妇科

第一机构：甘肃中医药大学临床医学院

年份：2020

卷号：41

期号：4

起止页码：260

中文期刊名：西北国防医学杂志

外文期刊名：Medical Journal of National Defending Forces in Northwest China

基金：甘肃中医药大学研究生创新基金(2019CX35)。

语种：中文

中文关键词：卵巢癌;ABC转运蛋白;多药耐药;ABCA亚群;ABCB亚群

外文关键词：ovarian cancer;ABC transporter;multidrug resistance ABCA subset;ABCB subset

摘要：卵巢癌(ovarian cancer,OC)是女性癌症相关死亡的主要原因之一,>80%的OC患者会产生多药耐药(multidrug resistance,MDR),这导致了OC的不良预后。三磷酸腺苷(adenosine triphosphate,ATP)结合盒(ATP-binding cassette,ABC)家族,即ABC转运蛋白相关的耐药机制是公认的产生MDR的原因之一。各种ABC转运蛋白在化疗后出现异常表达增加,导致化疗药物在细胞内的积聚减少,从而影响化疗效果,减少OC患者生存期。虽然目前对于ABC转运蛋白抑制剂的临床试验尚无明确结论,但ABC转运蛋白抑制剂的研究对于完善OC治疗仍具有一定意义。了解ABC转运蛋白的功能及其在OC化疗耐药中的作用,对开发更有效的靶向药物具有现实意义。本研究针对ABC转运蛋白中ABCA亚群及ABCB亚群中的一些常见成员对OC的影响进行综述。
Ovarian cancer(OC)is one of the leading causes of cancer-related death in women.More than 80%of OC patients develop multipledrug resistance,which leads to a poor prognosis of OC.The adenosine triphosphate(ATP)binding cassette(ABC)family,also called the drug resistance mechanism associated with ABC transporters,is a recognized cause of multidrug resistance.The abnormal expression of various ABC transporters after chemotherapy leads to the decrease of the accumulation of chemotherapeutic drugs in cells,which affects the results of chemotherapy and reduces the survival time of OC patients.Although there is no clear conclusion on the clinical trials of ABC transporter inhibitors at present,the study of ABC transporter inhibitors still has a certain significance for improving the treatment of OC.Understanding the function of ABC transporter and its role in OC chemotherapy resistance is of practical significance for the development of more effective targeted drugs.This article reviews the effects of ABCA subsets of ABC transporters and some common members of ABCB subsets on OC.