文献类型：期刊文献

中文题名：大麻素1型受体参与疼痛调节机制的研究进展

英文题名：Research progress of cannabinoid type 1 receptors involved in pain modulation mechanism

作者：周婷[1];李文娟[2];刘荣鑫[1];张杰[2];薛建军[2]

第一作者：周婷

机构：[1]甘肃中医药大学第一临床医学院,730000;[2]甘肃省中医院麻醉科

第一机构：甘肃中医药大学临床医学院

年份：2024

卷号：40

期号：6

起止页码：648

中文期刊名：临床麻醉学杂志

外文期刊名：Journal of Clinical Anesthesiology

收录：CSTPCD;;北大核心:【北大核心2023】；CSCD:【CSCD_E2023_2024】；

基金：甘肃省科技计划项目(21JR7RA586,20JR10RA435)。

语种：中文

中文关键词：大麻素1型受体;疼痛;镇痛机制;内源性大麻素

外文关键词：Cannabinoid type 1 receptor;Pain;Analgesic mechanism;Endogenous cannabinoid

摘要：大麻素1型受体(CB1R)是近年来研究较为广泛的内源性大麻素受体之一,在中枢和外周神经系统均有表达。CB1R位于突触前膜,通过逆行抑制性突触传递调节神经递质的释放,是治疗疼痛的有效靶点。激活CB1R对伤害性、病理性和炎性疼痛均具有镇痛效应,拮抗CB1R可引起疼痛敏化。本文通过对CB1R结构功能、信号转导、镇痛机制方面进行综述,为进一步了解疼痛的病理生理学机制及探索更优疼痛治疗方法提供参考。
Cannabinoid type 1 receptor(CB1R) is one of the most widely studied endocannabinoid receptors in recent years,which is expressed in both central and peripheral nerve systems.CBIR is located in the presynaptic membrane,and regulates the release of neurotransmitters through retrograde inhibitory synaptic transmission,which is an effective target for the treatment of pain.Activation of CB1R has analgesic effect on injurious,pathological,and inflammatory pain,and antagonism of CB1R can cause pain sensitization.This article describes CB1R from the aspects of structure and function,signal transduction,and analgesic mechanism,so as to provide reference for further understanding the pathophysiology of pain and exploring better pain treatment methods.