文献类型：期刊文献

英文题名：Predictive value of MEP1A in cancer prognosis A protocol for systematic review and meta-analysis

作者：Chen, Yong[1];Wu, Fangfang[2];Zhang, Li[3];Du, Li[4];Yan, Xiang[1]

第一作者：Chen, Yong

通信作者：Yan, X[1]

机构：[1]Lanzhou Univ, Hosp 1, 1 Donggang West Rd, Lanzhou, Gansu, Peoples R China;[2]Lanzhou Univ, Evidence Based Nursing Ctr, Sch Nursing, Lanzhou, Peoples R China;[3]Gansu Univ Chinese Med, Ward 3, Cardiovasc Clin Med Ctr, Affiliated Hosp, Lanzhou, Peoples R China;[4]Third Peoples Hosp Lanzhou City, Lanzhou, Peoples R China

第一机构：Lanzhou Univ, Hosp 1, 1 Donggang West Rd, Lanzhou, Gansu, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Hosp 1, 1 Donggang West Rd, Lanzhou, Gansu, Peoples R China.

年份：2020

卷号：99

期号：45

外文期刊名：MEDICINE

收录：;Scopus(收录号：2-s2.0-85095800898);WOS:【SCI-EXPANDED(收录号:WOS:000588168200083)】；

基金：This project was funded by Development and promotion of mental health tracking and intervention database for pediatric medical staff in Gansu Province (Grant No. 2018-RC-52).

语种：英文

外文关键词：cancer; MEP1A; prognosis; systematic review

摘要：Background: Meprin is a member of the astaxanthin family; it performs many functions through a wide range of proteolytic enzyme activities during health and disease, including tumors and inflammatory conditions. The purpose of this systematic review was to evaluate the predictive value of MEP1A in tumor prognosis. Methods: A comprehensive search was conducted on PubMed, Cochrane library, and Web of Science Database using a developed search strategy. The Newcastle-Ottawa Scale (NOS) or the Cochrane Collaboration's tool for assessing risk of bias will be used to access the methodological quality of included studies, and GRADE will be applied to evaluate evidence quality of outcomes. All analyses were performed by Stata 15.0. Results: The results will systematically summarize and display the currently collected evidence on the predictive value of MEP1A in different tumor prognosis. Conclusion: This study may play a certain role in predicting the prognosis of cancer patients in the future, and may prompt clinicians to make necessary treatment or prevention plans as soon as possible. Ethics and communication: It is not necessary because the present systematic review is based on published studies. INPLASY registration number: INPLASY2020100005.