文献类型：期刊文献

中文题名：中医药调控ROS防治阿尔茨海默病研究进展

英文题名：Prevention and Treatment of Alzheimer's Disease by Traditional Chinese Medicine via Regulating ROS:A Review

作者：王佳伟[1];魏本君[1,2]

第一作者：王佳伟

机构：[1]甘肃中医药大学,兰州730000;[2]甘肃中医药大学甘肃省中医方药挖掘与创新转化重点实验室,敦煌医学与转化教育部重点实验室,兰州730000

第一机构：甘肃中医药大学

年份：2024

卷号：30

期号：12

起止页码：281

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;Scopus;北大核心:【北大核心2023】；CSCD:【CSCD2023_2024】；

基金：甘肃省教育科技创新项目创新基金项目(2022B-116);甘肃中医药大学引进人才项目(2018YJRC-06);甘肃省中医方药挖掘与创新转化重点实验室开放基金项目(zyzx-2020-11)。

语种：中文

中文关键词：中医药;阿尔茨海默病(AD);氧化应激(OS);β淀粉样蛋白(Aβ);Tau样蛋白磷酸化;活性氧(ROS)

外文关键词：traditional Chinese medicine;Alzheimer's disease(AD);oxidative stress(OS);amyloidbeta protein(Aβ);Tau protein phosphorylation;reactive oxygen species(ROS)

摘要：阿尔茨海默病(AD)病理机制十分复杂,有多种假说,β-淀粉样蛋白(Aβ)和Tau样蛋白磷酸化是其主流学说。氧化应激(OS)是其他假说和机制的连接桥梁,在多种假说中有关键作用。因此,针对ADOS的治疗有利于缓解疾病进展。活性氧(ROS)既是一种氧化剂,也是一种氧化产物,与Aβ和Tau样蛋白相互作用,活化小胶质细胞及星形胶质细胞,触发炎症和线粒体功能障碍,导致脑内环境恶化,加快疾病发生发展。ROS作为诱导OS的信号使者广泛参与了AD疾病进程,可能是AD疾病进展的新靶点。中药单体及复方在AD的防治中起到越来越重要的作用,最新研究发现中医药有效防治AD与调控ROS关系密切。从ROS探讨中医药治疗AD发生发展的作用机制的研究较多,但尚缺乏系统综述。该文通过分析汇总近年来国内外文献,从ROS的产生及生理,在AD的作用机制及中医药通过相关途径调控ROS防治AD方面进行综述,为中医药对ROS调控研究提供参考,以期为防治AD提供新靶点和新方法。
The pathological mechanism of Alzheimer's disease(AD)is complex,and there are many hypotheses.The mainstream theory is the amyloid-beta protein(Aβ)and Tau protein phosphorylation.Oxidative stress(OS)is a bridge between other hypotheses and mechanisms and plays a key role in many hypotheses.Therefore,the treatment of OS in AD(ADOS)is beneficial in alleviating disease progression.Reactive oxygen species(ROS)is a kind of antioxidant and a kind of oxidation products,with Aβand Tau protein interactions,activating microglia and astrocytes,triggering inflammation and mitochondrial dysfunction,leading to the deterioration of the environment in the brain,and accelerating the development of disease.ROS,as a signal messenger inducing OS,is widely involved in the progression of AD and may be a new target for the progression of AD.Traditional Chinese medicine(TCM)monomers and compounds play an increasingly important role in the prevention and treatment of AD.Recent studies have found that the effective prevention and treatment of AD by TCM is closely related to the regulation of ROS.There are many studies on the mechanism of TCM in the treatment of AD via regulating ROS,but there is a lack of systematic review.By analyzing and summarizing the literature in China and abroad in recent years,this paper reviewed the generation and physiology of ROS,the mechanism of action of AD,and the prevention of AD by TCM via regulating ROS through relevant ways,so as to provide references for the research on the regulation of ROS by TCM and provide new targets and new methods for the prevention and treatment of AD.