文献类型：期刊文献

英文题名：The role of eosinophils and basophils in peripheral blood in liver injury: findings from a cross-sectional study of an external hospital-based dataset and the NHANES (2007-2012)

作者：Gao, Shan[1,2,3];Du, Kewei[1,2,3];Zhang, Meilong[4];Ma, Yue[1,2,3];He, Juanhong[1,2,3];Che, Tuanjie[5];Li, Linjing[1,2,3];Zhang, Shangdi[1,2,3]

第一作者：Gao, Shan

通信作者：Li, LJ[1];Zhang, SD[1];Li, LJ[2];Zhang, SD[2];Li, LJ[3];Zhang, SD[3]

机构：[1]Lanzhou Univ, Hosp 2, Lab Med Ctr, Lanzhou, Peoples R China;[2]Lanzhou Univ, Clin Med Sch, Lanzhou, Peoples R China;[3]Lanzhou Univ, Hosp 2, Cuiying Biomed Res Ctr, Lanzhou, Peoples R China;[4]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou, Peoples R China;[5]Innovat Ctr Funct Genom & Mol Diagnost Technol Gan, Lanzhou, Peoples R China

第一机构：Lanzhou Univ, Hosp 2, Lab Med Ctr, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Hosp 2, Lab Med Ctr, Lanzhou, Peoples R China;[2]corresponding author), Lanzhou Univ, Clin Med Sch, Lanzhou, Peoples R China;[3]corresponding author), Lanzhou Univ, Hosp 2, Cuiying Biomed Res Ctr, Lanzhou, Peoples R China.

年份：2026

卷号：17

外文期刊名：FRONTIERS IN PHYSIOLOGY

收录：;Scopus(收录号：2-s2.0-105047406854);WOS:【SCI-EXPANDED(收录号:WOS:001847357500001)】；

基金：The author(s) declared that financial support was received for this work and/or its publication. This research was funded by the Young Scholars Innovation Foundation of Lanzhou city (Grant Nos. 2024-QN-19), Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital (Grant Nos. CY2024-MS-B15, CY2025-MS-A12, CY2024-ZD-01), General Projects of Gansu Provincial Joint Research Fund (23JRRA1503), Chengguan District Talent Innovation and Entrepreneurship Project in Lanzhou city (2024-rc-2), Key Research and Development Program of Gansu Province(25YFFA052), Lanzhou Science and Technology Plan Project (2025-2-88).

语种：英文

外文关键词：basophil count; eosinophil count; liver injury; NHANES; prognostic biomarker

摘要：Background As a major global health concern, liver injury requires effective preventive and therapeutic measures. This study aimed to examine the relationship between eosinophil and basophil counts and liver injury.Methods We analyzed two cohorts: 16, 328 subjects from a hospital-based dataset and 14, 962 individuals from the NHANES (2007-2012) database. After excluding cases with missing values, participants were categorized into groups with or without liver injury. Statistical analyses included weighted logistic regression (across three models), the XGBoost algorithm to identify critical factors, and restricted cubic spline analysis to explore non-linear relationships.Results Statistical analyses revealed significant differences in eosinophil and basophil counts in peripheral blood between the liver injury and non-injury groups. Weighted logistic regression demonstrated a significant association between these cell counts and liver injury across all three models, independent of other covariates. The XGBoost algorithm identified eosinophil and basophil counts as critical factors for liver injury, ranking second and third in importance after age. Restricted cubic spline analysis showed a non-linear relationship between eosinophil count and the odds ratio (OR), with an optimal count of 0.2 & times;109 cells/L. Furthermore, higher eosinophil and basophil counts were correlated with reduced overall survival (OS) in patients with liver injury.Conclusion These findings highlight eosinophil and basophil counts as potential risk factors for liver injury, providing valuable insights for its prevention and treatment.