文献类型：期刊文献

英文题名：Comprehension of the α-Arylation of Nitroalkanes

作者：Zheng, Peng-Fei[1];An, Yang[2,3];Jiao, Zuo-Yi[1];Shi, Zhou-Bao[4];Zhang, Fu-Min[2,3]

第一作者：Zheng, Peng-Fei

通信作者：Jiao, ZY[1];Zhang, FM[2];Zhang, FM[3]

机构：[1]Lanzhou Univ, Hosp 2, Dept Gen Surg, Lanzhou 730000, Gansu, Peoples R China;[2]Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China;[3]Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Gansu, Peoples R China;[4]Gansu Univ Chinese Med, Affiliate Hosp, Lanzhou 730000, Gansu, Peoples R China

第一机构：Lanzhou Univ, Hosp 2, Dept Gen Surg, Lanzhou 730000, Gansu, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Hosp 2, Dept Gen Surg, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China;[3]corresponding author), Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Gansu, Peoples R China.

年份：2019

卷号：23

期号：14

起止页码：1560

外文期刊名：CURRENT ORGANIC CHEMISTRY

收录：;EI(收录号：20241916059459);Scopus(收录号：2-s2.0-85075003215);WOS:【SCI-EXPANDED(收录号:WOS:000490547000007)】；

基金：We are grateful to the NSFC (Nos. 21772076 and 21971095) and PCSIRT of MOE (No. IRT-15R28) for supporting this work.

语种：英文

外文关键词：Comprehension; nitroalkane; alpha-arylation; synthesis; advance; asymmetric

摘要：Background: alpha-Aryl substituted nitroalkanes are important synthetic intermediates for the preparation of pharmaceutical molecules, natural products, and functional materials. Due to their scare existence in Nature, synthesis of these compounds has attracted the attention of synthetic and medicinal chemists, rendering alpha-arylation of nitroalkanes of an important research topic. This article summarizes the important advances of alpha-arylation of nitroalkanes since 1963. Results: After a brief introduction of the synthetic application and the reactions of nitroalkanes, this article reviewed the synthetic methods for the alpha-arylated aliphatic nitro compound. The amount of research on alpha-arylation of nitroalkanes using various arylation reagents and the discovery of elegant synthetic approaches towards such skeleton have been discussed. This review described these advances in two sections. One is the arylation of non-activated nitroalkanes, with an emphasis on the application of diverse arylation reagents; the other focuses on the arylation of activated nitroalkanes, including dinitroalkanes, trinitroalkanes, alpha-nitrosulfones, alpha-nitroesters, alpha-nitrotoluenes, and alpha-nitroketones. The synthetic application of these methods has also been presented in some cases. Conclusion: In this review, we described the progress of alpha-arylation of nitroalkanes. Although the immense amount of research on alpha-arylation of aliphatic nitro compounds has been achieved, many potential issues still need to be addressed, especially the asymmetric transformation and its wide application in organic synthesis.