文献类型：期刊文献

中文题名：甘草有效成分抗肿瘤作用机制及联合抗肿瘤研究进展

英文题名：Anti-tumor Mechanism of Active Ingredients of Glycyrrhizae Radix et Rhizoma and Its Combined Use in Anti-tumor Treatment:A Review

作者：连小龙[1];令颖[1];张尚龙[1];马趣环[1];闫潇[1];张楠[1];叶立巧[1];邓毅[1,2]

第一作者：连小龙

机构：[1]甘肃中医药大学药学院,兰州730000;[2]甘肃省中药药理与毒理学重点实验室,兰州730000

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

年份：2022

卷号：28

期号：11

起止页码：238

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

基金：国家自然科学基金地区基金项目(81960723);甘肃省教育科技创新项目(2021CXZX-749)。

语种：中文

中文关键词：甘草;甘草有效成分;抗肿瘤;作用机制;联合抗肿瘤

外文关键词：Glycyrrhizae Radix et Rhizoma;active ingredients of Glycyrrhizae Radix et Rhizoma;anti-tumor;mechanism;combined anti-tumor

摘要：甘草为我国传统药材,古有“十方九草”之说。现代药理学研究表明,甘草具有抗肿瘤、抗炎杀菌、抗病毒、保肝、抗心衰、调节免疫及抗纤维化等作用。恶性肿瘤是由于多种因素引起的一种发病机制比较复杂的疾病,是全世界面临的重大难题,也是我国居民死亡的主要原因之一,相关统计数据显示,恶性肿瘤的发病率和死亡率呈不断增加趋势,且年轻化,严重威胁人们的健康安全,临床对其治疗主要以放化疗为主。目前临床多数抗肿瘤药物无选择性,在杀灭肿瘤细胞的同时对正常细胞也有严重损伤,对机体重要器官有一定损伤,且长期用药还会降低肿瘤细胞的敏感性,传统中医药辨证论治思想和多成分、多靶点的特性使其在抗肿瘤中具有一定的优势。有研究显示,中药与抗肿瘤药物联合用药在增强抗肿瘤作用的同时,还能降低毒性,故从中医药中寻找新的抗肿瘤药物成为一大热点。近年来,甘草有效成分在抗肝癌、乳腺癌、肺癌、结肠癌等肿瘤及联合抗肿瘤方面的研究取得了一定进展,在此研究基础上,通过对其诱导细胞凋亡、干扰细胞周期、诱导自噬、抑制糖酵解、调节免疫、调控miRNA和信号通路等作用机制,以及联合抗肿瘤增效减毒、增敏进行分析总结,为甘草有效成分的进一步开发和临床应用提供理论基础和研究思路。
As a traditional Chinese medicinal material,Glycyrrhizae Radix et Rhizoma has been extensively used in various formulae.According to modern pharmacological research,it has anti-tumor,antiinflammatory,anti-viral,liver-protecting,anti-heart failure,immunoregulatory,and anti-fibrosis effects.Caused by the interaction of various factors,cancer features complex pathogenesis.It is a global challenge and one of the main causes of death in China.Statistics show that the morbidity and mortality of malignant tumors have been on the rise,particularly for the young,which threaten the health of human beings.At the moment,radiotherapy and chemotherapy are the main countermeasures.Most clinical anti-tumor drugs demonstrate nonselective toxicity.To be specific,they damage normal cells while killing tumor cells,thus injuring vital organs.In addition,long-term medication will reduce the sensitivity of tumor cells.However,traditional Chinese medicine,which is characterized by treatment based on syndrome differentiation,multiple components,and multiple targets,is superior in the treatment of tumor.Studies have shown that the combination of anti-tumor drugs with Chinese medicine can not only enhance the anti-tumor effect but also alleviate toxicity.Therefore,it has been a research hotspot to develop anti-tumor drugs based on traditional Chinese medicine.In recent years,major headway has been made in the research on active ingreddients of Glycyrrhizae Radix et Rhizoma in antiliver cancer,anti-breast cancer,anti-lung cancer,and anti-colon cancer and the combination with other drugs for anti-tumor.On this basis,we summarized the mechanisms of active ingredients of Glycyrrhizae Radix et Rhizoma in inducing apoptosis,interfering with cell cycle,inducing autophagy,inhibiting glycolysis,regulating immunity,and modulating miRNA and signaling pathways,as well as the combination with other drugs in anti-tumor efficiency,toxicity reduction,and sensitivity enhancement,hoping to lay a theoretical basis for the further development and clinical application of active ingredients of Glycyrrhizae Radix et Rhizoma.