文献类型：期刊文献

中文题名：初步探讨针刺治疗对卵巢过度刺激综合征(OHSS)的影响

英文题名：Influence of Acupuncture on Ovarian Hyperstimulation Syndrome(OHSS)

作者：何晓霞[1];张学红[1];魏清琳[2]

第一作者：何晓霞

机构：[1]兰州大学第一医院生殖医学中心,兰州730000;[2]甘肃中医学院附属医院,兰州730000

第一机构：兰州大学第一医院生殖医学中心,兰州730000

年份：2011

卷号：31

期号：12

起止页码：817

中文期刊名：生殖与避孕

外文期刊名：Reproduction and Contraception

收录：CSTPCD;;北大核心:【北大核心2008】；CSCD:【CSCD2011_2012】；

基金：甘肃省中医药科学技术研究"中药及针刺疗法在辅助生殖技术中的应用研究"重点课题;课题编号:GZK-2010-Z5

语种：中文

中文关键词：针刺治疗;IVF/ICSI-ET;卵巢过度刺激综合征(OHSS);临床妊娠率

外文关键词：acupuncture; IVF/ICSI-ET; ovarian hyperstimulation syndrome（OHSS）; clinical pregnancy rate

摘要：目的:探讨针刺治疗在体外受精/卵胞质内单精子显微注射-胚胎移植(IVF/ICSI-ET)治疗过程中对卵巢过度刺激综合征(OHSS)的发生所产生的影响。方法:将进行IVF/ICSI-ET治疗的304例不孕症患者随机分为针刺治疗组(研究组)和对照组。采用黄体期促性腺激素释放激素激动剂(GnRH-a)长方案进行控制性超促排卵,研究组患者从控制性超促排卵第1日开始接受针刺治疗,直至胚胎移植日(取卵日不进行针刺治疗),对照组不作针刺治疗,其余同研究组。观察比较研究组和对照组促性腺激素(Gn)用量、血清雌二醇(E2)水平、OHSS发生率、获卵数、临床妊娠率和流产率等。结果:①研究组OHSS的发生率低于对照组(2.03%vs 7.33%,P<0.05);②研究组胚胎移植日血清E2水平低于对照组(P<0.05);③研究组临床妊娠率和流产率与对照组相比均无统计学差异(52.90%vs 50.74%,P>0.05;10.96%vs 10.14%,P>0.05).结论:针刺辅助治疗对降低IVF-ET治疗过程中OHSS的发生起到一定的作用。
Objective： To investigate the effects of acupuncture on the occurence of ovarian hyperstimulation syndrome（OHSS） under the in vitro fertilization/intracytoplasmic sperm injection-embryo transfer（IVF/ICSI-ET） treatment.Methods： A total of 304 patients under the treatment of IVF-ET/ICSI were randomly allocated to experimental group or control group.Both groups were treated with long protocol of gonadotropin releasing hormone agonist（GnRH-a）.The patients in experimental group received acupuncture from the first day of controlled ovarian hyperstimulation to embryo transfer day（exclude the day of oocyte retrieval）.Dose of gonadotropin（Gn）,days of treatment were observed.Level of serum estradiol（E2） was detected by chemiluminescence.The incidence of OHSS,the number of oocytes,clinical pregnancy rate and miscarriage rate were compared.Results： 1） Compared with the control,the incidence of OHSS significantly reduced in experimental group（2.03% versus 7.33%,respectively,P0.05）;2） Serum E2 of the embryo transferred day was significantly lower in experimental group than that in the control（P0.05）;3） The clinical pregnancy rate of experimental group was not different from the control（52.90% versus 50.74%,respectively,P0.05）.No significant differences were found in miscarriage rate between the two groups（10.96% versus 10.14%,respectively,P0.05）.Conclusion： Acupuncture used during IVF treatment plays a role in reducing the occurrence of OHSS.