文献类型：期刊文献

英文题名：Recent Advances in Natural Product Interventions on Cardiovascular Disease: The Role of Programmed Cell Death

作者：Yang, Liping[1];Wei, Huiping[2];Yang, Zhaodi[1];Gong, Yushuan[1];Liu, Xinyue[1];Xu, Baomei[1];Lu, Yunyan[3]

第一作者：杨丽萍

通信作者：Wei, HP[1]

机构：[1]Gansu Univ Chinese Med, Coll Tradit Chinese & Western Med, Lanzhou, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Affiliated Hosp, Dept Cardiol, 732 Jiayuguan West Rd, Lanzhou 730020, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Coll Clin Chinese Med, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp, Dept Cardiol, 732 Jiayuguan West Rd, Lanzhou 730020, Gansu, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2026

外文期刊名：AMERICAN JOURNAL OF CHINESE MEDICINE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001888968600001)】；

基金：This work was supported by the Gansu Provincial Administration of Traditional Chinese Medicine (No. GZKZ-2020-9), the Major Science and Technology Innovation Project in the Health Industry of Gansu Province (No. GSWSQNPY2025-21), the Gansu Provincial Natural Science Foundation (No. 25JRRA975), the Gansu Provincial Drug Administration (No. 2025GSMPA054), the Lanzhou Municipal Science and Technology Bureau Program (No. 2025-2-87), and the Gansu Provincial Administration of Traditional Chinese Medicine (No. GZKZ-2025-30).

语种：英文

外文关键词：Cardiovascular diseases; programmed cell death; natural products; cardioprotection; molecular mechanisms

摘要：Cardiovascular diseases (CVDs) remain one of the leading causes of morbidity and mortality worldwide, with cardiomyocyte death playing an important role in myocardial injury, pathological cardiac remodeling, and the progression of heart failure. Programmed cell death (PCD), including apoptosis, pyroptosis, ferroptosis, cuproptosis, and disulfidptosis, plays an essential role in maintaining cellular homeostasis; however, its aberrant activation or dysregulation can contribute to cardiovascular injury and disease progression. Increasing evidence indicates that these PCD pathways are not independent but form a complex regulatory network through shared mechanisms, including mitochondrial dysfunction, oxidative stress, inflammatory activation, and metabolic imbalance, thereby contributing collectively to the development and progression of CVDs. Therefore, targeting PCD-related pathways has emerged as a promising therapeutic strategy. Natural products and their bioactive constituents can exert cardioprotective effects by regulating PCD-related signaling networks through multiple targets and pathways, thereby alleviating cardiomyocyte death, oxidative stress, inflammation, and cardiac dysfunction. Representative bioactive compounds, including salvianolic acid B, resveratrol, quercetin, and astragaloside IV, have demonstrated potential to modulate PCD-related signaling pathways in experimental models of CVDs. This review summarizes the molecular mechanisms and pathological roles of apoptosis, pyroptosis, ferroptosis, cuproptosis, and disulfidptosis in CVDs, elucidates the regulatory crosstalk among different PCD pathways, and systematically reviews the research progress on the cardioprotective effects of natural products and their bioactive constituents through targeting PCD. In conclusion, natural products targeting dysregulated PCD pathways may represent a promising multi-target therapeutic strategy for cardiovascular protection; however, current evidence is derived predominantly from preclinical studies, and further in-depth mechanistic investigations and high-quality clinical studies are warranted to validate their therapeutic potential and clinical translational value.