详细信息
二十五味珍珠丸对实验性脑缺血大鼠脑毛细血管通透性及脑含水量的影响 被引量:15
Effects of Ershiwuwei Zhenzhu Wan on Cerebral Capillary Permeability and Cerebral Water Content in the Experimental Rats with Cerebral Ischemia
文献类型:期刊文献
中文题名:二十五味珍珠丸对实验性脑缺血大鼠脑毛细血管通透性及脑含水量的影响
英文题名:Effects of Ershiwuwei Zhenzhu Wan on Cerebral Capillary Permeability and Cerebral Water Content in the Experimental Rats with Cerebral Ischemia
作者:张黎明[1];刘生[2];马骏[3];吴国泰[3];任远[3]
第一作者:张黎明
机构:[1]甘肃省天水市第一人民医院药剂科,天水市741000;[2]甘肃省医药职工中专学校,兰州市730000;[3]甘肃中医学院,兰州市730000
第一机构:甘肃省天水市第一人民医院药剂科,天水市741000
年份:2006
卷号:17
期号:9
起止页码:664
中文期刊名:中国药房
外文期刊名:China Pharmacy
收录:CSTPCD;;北大核心:【北大核心2004】;CSCD:【CSCD_E2011_2012】;
语种:中文
中文关键词:二十五味珍珠丸;脑缺血;大鼠;脑水肿;预防作用
外文关键词:Ershiwuwei zhenzhu wan; Cerebral ischemia; Rats; Cerebral edema;Preventive effect
摘要:目的:研究二十五味珍珠丸对大鼠脑缺血所致脑水肿的影响。方法:建立以颈总动脉结扎致大鼠不完全性脑缺血模型,通过伊文氏蓝法和重量法观察二十五味珍珠丸对脑毛细血管通透性、脑指数、脑含水量的影响。结果:二十五味珍珠丸预防给药可明显降低模型大鼠脑毛细血管通透性、脑含水量和脑指数,减轻脑水肿(P<0.05)。结论:二十五味珍珠丸对实验性大鼠脑缺血所致脑水肿有一定的预防作用。
OBJECTIVE: To study the effects of Ershiwuwei zhenzhu wan(ZZW) on cerebral edema induced by cerebral ischemia of rats. METHODS: The incomplete cerebral ischemia model was induced by occlusion of arteria earotis in rats, the effects of ZZW on cerebral capillary permeability, cerebral index and cerebral water content were observed by azo - blue method and weighting method. RESULTS: Preventive medication of ZZW could significantly decrease cerebral capillary permeability, cerebral index and cerebral water content and palliate cerebral edema(P 〈(0.05), CONCLUSION: ZZW is proved to be of preventive effect on cerebral edema induced by cerebral ischemia of experimental rats.
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