文献类型：期刊文献

英文题名：Relationship between digestive diseases and COVID-19 severity and mortality A protocol for systematic review and meta-analysis

作者：Li, Jinjuan[1];Yue, Jia[1];Zhang, Shunan[1];Wu, Jianjun[1];Lian, Rongna[2];Zhang, Ruinian[2];Cheng, Peng[3]

第一作者：李金娟

通信作者：Wu, JJ[1]

机构：[1]Gansu Univ Chinese Med, Sch Publ Hlth, 35 Dingxi East Rd, Lanzhou 730000, Gansu, Peoples R China;[2]Lanzhou Univ, Clin Med Coll 1, Lanzhou, Peoples R China;[3]Lanzhou Univ, Dept Orthoped, Hosp 2, Lanzhou, Peoples R China

第一机构：甘肃中医药大学公共卫生学院

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Publ Hlth, 35 Dingxi East Rd, Lanzhou 730000, Gansu, Peoples R China.|[10735e9d5e7087247e71b]甘肃中医药大学公共卫生学院;[10735]甘肃中医药大学;

年份：2020

卷号：99

期号：48

起止页码：e23353

外文期刊名：MEDICINE

收录：;Scopus(收录号：2-s2.0-85096818604);WOS:【SCI-EXPANDED(收录号:WOS:000596048000051)】；

基金：This work was supported by the Gansu Youth Science and Technology Fund Project (17JR5RA235).

语种：英文

外文关键词：COVID-19; gastrointestinal disease; liver disease; meta-analysis; SARS-CoV-2

摘要：Background: Digestive diseases have been often reported in COVID-19 patients, but whether COVID-19 patients with existing digestive comorbidities are at an increased risk of serious disease and death remains unclear. This study aims to evaluate the association between digestive diseases and COVID-19 severity and mortality. Methods: PubMed, Embase.com, the Cochrane Central Register of Controlled Trials, Web of Science, China National Knowledge Infrastructure, Wanfang, and SinoMed will be searched to identify relevant studies up to October 1, 2020. We will use the Newcastle-Ottawa quality assessment scale to assess the quality of included studies. We will use Stata to perform pairwise meta-analyses using the random-effects model with the inverse variance method to estimate the association between digestive diseases and the mortality and severity of COVID-19. Subgroup analyses and sensitivity analyses will be conducted to investigate the sources of heterogeneity. We will create a "Summary of findings" table presenting our primary and secondary outcomes using the GRADEpro Guideline Development Tool software. Results: The results of this study will be published in a peer-reviewed journal. Conclusions: This study will comprehensively evaluate the association between digestive diseases and the severity and mortality of patients with COVID-19. The results of this study will provide high-quality evidence to support clinical practice and guidelines development.