文献类型：期刊文献

英文题名：The mechanism of gut-lung axis in pulmonary fibrosis

作者：Dong, Yawei[1,2];He, Lanlan[1,2];Zhu, Zhongbo[1,2];Yang, Fan[1,2];Ma, Quan[1,2,3];Zhang, Yanmei[1,2];Zhang, Xuhui[1,2,3];Liu, Xiping[1,2]

第一作者：Dong, Yawei

通信作者：Zhang, XH[1];Liu, XP[1];Zhang, XH[2];Liu, XP[2];Zhang, XH[3]

机构：[1]Gansu Univ Chinese Med, Key Lab Gansu Prov Prescript, Min & Innovat Translat Lab, Lanzhou, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Gansu Prov Tradit Chinese Med New Prod Creat Engn, Lanzhou, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Resp Med, Affiliated Hosp, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Key Lab Gansu Prov Prescript, Min & Innovat Translat Lab, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Chinese Med, Gansu Prov Tradit Chinese Med New Prod Creat Engn, Lanzhou, Gansu, Peoples R China;[3]corresponding author), Gansu Univ Chinese Med, Resp Med, Affiliated Hosp, Lanzhou, Gansu, Peoples R China.|[10735b845793de6ae2b30]甘肃中医药大学第二附属医院;[10735]甘肃中医药大学;

年份：2024

卷号：14

外文期刊名：FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

收录：;Scopus(收录号：2-s2.0-85185096105);WOS:【SCI-EXPANDED(收录号:WOS:001161539500001)】；

基金：The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by grants from National Natural Science Foundation of China (Grant No. 82260889), Major Science and Technology Projects-Social Development (22ZD1FA001), Provincial Natural Science Foundation of Gansu (Grant No. 20JR5RA165), Lanzhou Science and Technology Plan Project in Gansu Province (Grant No. 2021SHFZ0026).

语种：英文

外文关键词：pulmonary fibrosis; gut-lung axis; microbiome; metabolite; immune regulation; pathogenic mechanism; related treatment

摘要：Pulmonary fibrosis (PF) is a terminal change of a lung disease that is marked by damage to alveolar epithelial cells, abnormal proliferative transformation of fibroblasts, excessive deposition of extracellular matrix (ECM), and concomitant inflammatory damage. Its characteristics include short median survival, high mortality rate, and limited treatment effectiveness. More in-depth studies on the mechanisms of PF are needed to provide better treatment options. The idea of the gut-lung axis has emerged as a result of comprehensive investigations into the microbiome, metabolome, and immune system. This theory is based on the material basis of microorganisms and their metabolites, while the gut-lung circulatory system and the shared mucosal immune system act as the connectors that facilitate the interplay between the gastrointestinal and respiratory systems. The emergence of a new view of the gut-lung axis is complementary and cross-cutting to the study of the mechanisms involved in PF and provides new ideas for its treatment. This article reviews the mechanisms involved in PF, the gut-lung axis theory, and the correlation between the two. Exploring the gut-lung axis mechanism and treatments related to PF from the perspectives of microorganisms, microbial metabolites, and the immune system. The study of the gut-lung axis and PF is still in its early stages. This review systematically summarizes the mechanisms of PF related to the gut-lung axis, providing ideas for subsequent research and treatment of related mechanisms.