文献类型：期刊文献

英文题名：Distal pancreatectomy with En bloc celiac axis resection for locally advanced pancreatic body/tail cancer: A systematic review and meta-analysis

作者：Liu, Lu[1,2];Liu, Tian-Xiang[2];Huang, Wan-Xia[3];Yang, Zhong[2];Wang, Shang[1];Da, Ming-Xu[2];Dong, Yang[4]

第一作者：Liu, Lu;刘璐

通信作者：Da, MX[1];Dong, Y[2]

机构：[1]Gansu Univ Tradit Chinese Med, Coll Clin Med, Lanzhou, Peoples R China;[2]Gansu Prov Hosp, Dept Surg Oncol, 204 Donggang West Rd, Lanzhou 730000, Peoples R China;[3]Ningxia Med Univ, Coll Clin Med, Yinchuan, Ningxia, Peoples R China;[4]Zhejiang Univ, Affiliated Hosp 1, Sch Med, 79 Qingchun Rd, Hangzhou 310000, Peoples R China

第一机构：甘肃中医药大学临床医学院

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Surg Oncol, 204 Donggang West Rd, Lanzhou 730000, Peoples R China;[2]corresponding author), Zhejiang Univ, Affiliated Hosp 1, Sch Med, 79 Qingchun Rd, Hangzhou 310000, Peoples R China.

年份：2022

卷号：45

期号：1

起止页码：51

外文期刊名：ASIAN JOURNAL OF SURGERY

收录：;Scopus(收录号：2-s2.0-85108852271);WOS:【SCI-EXPANDED(收录号:WOS:000754520800007)】；

基金：This study was supported by the Health Industry Scientific Research Program of Gansu Province (Nos. GSWSKY-2019-04) and the Youth Project of Gansu Provincial People's Hospital (Nos. 18GSSY5-9).

语种：英文

外文关键词：Locally advanced pancreatic body; tail; cancer; Distal pancreatectomy; Celiac axis resection; Meta -analysis

摘要：Distal pancreatectomy with En-bloc celiac axis resection (DP-CAR) is a challenging procedure that has yielded certain clinical efficacy in the treatment of locally advanced pancreatic body/tail cancer, especially in patients with invasion of abdominal vessels. However, the clinical efficacy and safety of DP-CAR remain controversial. The study aimed to systematically review efficacy and safety of DP-CAR in the treatment of locally advanced pancreatic body/tail cancer. We systematically searched PubMed, EMBASE, Cochrane Library, and Web of Science databases from inception to 1 October 2020. Two studiers independently accomplished the study selection, data extraction, and quality assessment. Initially, of 1032 studies were searched, among which 11 high quality studies including 1072 patients were finally identified. The pooled results showed that DP-CAR versus Distal pancreatectomy (DP), the rate of R0 resection (RR = 0.76; 95%CI: 0.66 to 0.88; p = 0.0002) and 3-year survival (RR = 0.65; 95%CI: 0.43 to 0.98; p = 0.04) was lower, postoperative mortality (RR = 2.48; 95%CI: 1.02 to 6.03; p = 0.04) was higher, the operation time (MD = 104.67; 95%CI: 84.70 to 124.64; p < 0.001) and hospital stay (MD = 3.94, 95% CI 1.35 to 6.53; p = 0.003) were longer. There was no statistical difference between the DP-CAR and DP group in 1-year, 2-year survival rate (RR = 0.84; 95%CI: 0.57 to 1.23; p = 0.37) (RR = 0.70; 95%CI: 0.45 to 1.10; p = 0.12). In conclusion, compared with DP, DP-CAR has worse efficacy and prognosis survival and is more dangerous, but it can obtain better survival benefit and quality of life than palliative treatment. We suggest that DP-CAR can be carefully attempted for effective margin-negative resection. However, surgeons and patients need to know its potential perioperative risk. (c) 2021 Asian Surgical Association and Taiwan Robotic Surgery Association. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).