文献类型：期刊文献

英文题名：Association Between MTHFR Gene Polymorphism (A1298c) C>A and Sensitivity to Cervical Cancer A Meta-Analysis

作者：Chen, Yuanyuan[1,2];Ma, Shouye[1];Zhao, Tiaohong[1,2];Zhang, Tingting[1,2];Lu, Ruxia[1,2];Zhao, Yuanxu[1,2];Han, Xue[1];Liu, Huiling[1,2,3]

第一作者：Chen, Yuanyuan;陈云逸

通信作者：Liu, HL[1]

机构：[1]Gansu Prov Hosp, Dept Gynecol & Obstet, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Dept Clin Med 1, Lanzhou 730000, Gansu, Peoples R China;[3]Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China

第一机构：Gansu Prov Hosp, Dept Gynecol & Obstet, Lanzhou 730000, Gansu, Peoples R China

通信机构：[1]corresponding author), Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China.

年份：2024

卷号：22

期号：1

起止页码：135

外文期刊名：CURRENT TOPICS IN NUTRACEUTICAL RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001177241700044)】；

基金：This work was supported by Natural Science Foundation of Gansu Province (21JR1RA018) , Key Subject Project of Gansu Provincial Hospital (20GSSY1-4) , "experimental study of reduction responsive PLGA nanoparticles coated with ENO1 monoclonal antibody in the treatment of cervical cancer" and Natural Science Foundation of Gansu Province (21JR1RA018) , "Experimental study on the effect and mechanism of ENO1 monoclonal antibody against cervical cancer stem cells".

语种：英文

外文关键词：A1298C; Case-control study; Cervical cancer; Meta-analysis; Methylenetetrahydrofolate reductase; Polymorphism

摘要：We have investigated the association between methylenetetrahydrofolate reductase A1298C polymorphism and cervical cancer. A comprehensive search was conducted in Wanfang, China HowNet and PubMed databases to retrieve Chinese and English literature from the construction of the database to December 2019. Stata software was utilized to conduct the analysis of the five genetic models, while the odds ratio and 95% confidence interval were employed to assess the correlation. 12 pertinent publications were included with 3839 subjects (1546 patients and 2293 healthy control). There were no significant associations between A1298C and cervical cancer risk under recessive model, dominant model, allele model, co -dominant model. In the sub -analysis by ethnic groups, a significant association between A1298C and cervical cancer risk under recessive model in Asia. It is suggested a potential association between methylenetetrahydrofolate reductase gene polymorphism A1298C and an elevated susceptibility to cervical cancer in the Asian population, specifically under the recessive model.