文献类型：期刊文献

中文题名：微小RNA对肝癌糖代谢调节机制的研究进展

英文题名：Research progressions on the mechanism of microRNA regulation of glucose metabolism in Hepatocellular carcinoma

作者：常钰玲[1];陈彻[1];刘芳[1];牛亚倩[1];赵川[1]

第一作者：常钰玲

机构：[1]甘肃中医药大学临床医学院

第一机构：甘肃中医药大学临床医学院

年份：2019

卷号：11

期号：2

起止页码：79

中文期刊名：消化肿瘤杂志：电子版

收录：CSTPCD

基金：国家自然科学基金项目(81460456)

语种：中文

中文关键词：微小RNA;肝癌;糖代谢;关键酶;信号通路

外文关键词：MicroRNAs;Hepatocellular carcinoma;Glucose metabolism;Key enzymes;Signal pathway

摘要：肝癌是世界上最常见的恶性肿瘤之一,并且发病率逐年增加,尤其是在中国。尽管关于肝癌生物代谢过程的研究越来越多,许多肿瘤抑制剂或癌基因的转录调控机制尚不清楚。微小RNA (MicroRNAs, miRNAs)是长约19~25个核苷酸的单链非编码RNA,可在转录后影响基因的表达和很多生物学过程,包括肝癌糖代谢。糖代谢受多种基因,分子形式的调节,本文从二个方面系统阐释微小RNA对肝癌细胞糖代谢的影响,并展望其在临床的应用。
Liver cancer is one of the most common malignant tumors in the world, and the incidence rate has increased year by year, especially in China. Although there are more and more studies on the biological metabolism of liver cancer, the transcription and regulation mechanism of many tumor inhibitors or oncogenes is still unclear. MicroRNA is a single-stranded non-coding RNA of about 19 to 25 nucleotides that can affect gene expression and many biological processes after transcription, including glucose metabolism of liver cancer. Glucose metabolism is regulated by various genes and molecular. This paper will explain the effects of miRNA on glucose metabolism in Hepatocellular carcinoma systematically from two aspects and looks forward to its clinical application.