文献类型：期刊文献

英文题名：Early blood pressure drop predicts renal function deterioration and mortality in ICU patients with liver failure: a retrospective cohort study

作者：Guo, Rubing[1,2,3];Tong, Jingjing[4];Wang, Li[2];Yang, Bo[2];Ma, Liang[1];Cao, Yongtong[1];Zhao, Wei[1]

第一作者：Guo, Rubing

通信作者：Ma, L[1];Cao, YT[1];Zhao, W[1]

机构：[1]China Japan Friendship Hosp, Dept Clin Lab, Beijing 100029, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Sch Publ Hlth, Lanzhou 730000, Peoples R China;[3]Gansu Prov Hosp, Dept Clin Lab, Lanzhou 730000, Peoples R China;[4]China Japan Friendship Hosp, Dept Infect Dis, Beijing 100029, Peoples R China

第一机构：China Japan Friendship Hosp, Dept Clin Lab, Beijing 100029, Peoples R China

通信机构：[1]corresponding author), China Japan Friendship Hosp, Dept Clin Lab, Beijing 100029, Peoples R China.

年份：2025

卷号：49

期号：3

起止页码：145

外文期刊名：MEDICINA INTENSIVA

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001439549000001)】；

基金：This work was supported by the National High Level Hospital Clinical Research Funding [grant number 2023-NHLHCRF-PY-04] ; the Wu Jieping Medical Foundation [grant number 320.6750.2023-06-60] ; and the Research Projects of Gansu Provincial Hospital [grant number 23GSSYD-25] .

语种：英文

外文关键词：Liver failure; Renal function; Blood pressure; Critical care; Prognosis

摘要：Objective: To investigate the association between early blood pressure drop and worsening renal function (WRF) in ICU patients with liver failure and to evaluate their clinical outcomes. Design: Retrospective observational study. Setting: Intensive Care Medicine. Patients: Patients admitted to the ICU for the first time during their first hospitalization; diagnosed with liver failure according to the International Classification of Diseases, Ninth and Tenth Revision codes; and aged >= 18 years were included. Patients with a peak systolic blood pressure (SBP) drop of <0 mmHg were excluded. Intervention: We analyzed data of ICU patients with liver failure from the Medical Information Mart for Intensive Care IV version 2.2 database. Descriptive statistics, analysis of variance, Kruskal-Wallis test, and chi-square test were employed for analysis. Multivariate linear regression models were used to assess the determinants of blood pressure decline. Cox proportional hazards and generalized additive models were used to evaluate MAIN VARIABLES OF INTEREST: The relationship between blood pressure decline, WRF, and 60-day in-hospital mortality were evaluated, along with subgroup analyses. Results: Peak SBP drop was independently associated with higher risks of WRF (P < 0.001) and 60-day in-hospital mortality (P < 0.001), even after adjusting for potential confounders, including baseline SBP. The independent risk relationship observed between peak diastolic blood pressure, mean arterial pressure drop, and the occurrence of WRF and 60-day in-hospital mortality was similar. Conclusions: In ICU patients with liver failure, a significant early drop in blood pressure was associated with a higher incidence of WRF, increased risk of 60-day in-hospital mortality, and poorer prognoses.