文献类型：期刊文献

英文题名：Epigenetic orchestration of scar formation: Therapeutic potential of targeting DNA methylation and non-coding RNAs in cutaneous fibrosis (Review)

作者：Li, Jinshun[1];Liu, Weiyun[1];Yang, Jin[1];Li, Yanan[1]

第一作者：Li, Jinshun

通信作者：Li, YN[1]

机构：[1]Gansu Univ Chinese Med, Affiliated Hosp 3, Dept Burns & Plast Surg, 222 Silong Rd, Baiyin 730900, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Affiliated Hosp 3, Dept Burns & Plast Surg, 222 Silong Rd, Baiyin 730900, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2026

卷号：34

期号：1

外文期刊名：MOLECULAR MEDICINE REPORTS

收录：;Scopus(收录号：2-s2.0-105040548567);WOS:【SCI-EXPANDED(收录号:WOS:001792329600001)】；

语种：英文

外文关键词：epigenetics; DNA methylation; non-coding RNAs; cutaneous fibrosis; scar formation; therapeutic targeting; drug delivery

摘要：Cutaneous fibrosis is sustained by epigenetic 'memory' rather than chronic inflammation. DNA hypermethylation, repressive histone marks and non-coding RNA networks lock dermal fibroblasts into a collagen-secretory state that can persist years after wounding. Single-cell methylomes have identified DNA methyltransferase (DNMT)3B as the key epigenetic writer driving anti-fibrotic gene silencing, whereas N6-methyladenosine-modified long non-coding RNAs and reinforce these loops by tethering methylation machinery to chromatin. Local delivery of DNMT inhibitors, microRNA-29 mimics or antisense oligonucleotides via dissolvable microneedles, metal-organic framework patches or exosome arrays reproducibly reduces scar volume by 25-55% in pre-clinical models without systemic exposure of therapeutic agents. The present review integrates multi-omic mechanistic data with emerging device platforms to chart a precision roadmap for converting scar-forming repair into scar-sparing regeneration.