文献类型：期刊文献

英文题名：Characteristics of type 1 diabetes in Northwest China: A multicenter hospital-based study

作者：Zhang, Yue[1,2];Liu, Xiaoning[3];Yang, Xueni[2,4];Zhang, Yujie[2,4];Shang, Mengmeng[2,4];Tian, Limin[5]

第一作者：Zhang, Yue

通信作者：Tian, LM[1]

机构：[1]Lanzhou Univ, Sch Clin Med 1, Lanzhou, Peoples R China;[2]Gansu Prov Hosp, Dept Endocrinol, Lanzhou, Peoples R China;[3]Lanzhou Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Lanzhou, Peoples R China;[4]Gansu Univ Tradit Chinese Med, Clin Med Coll 1, Lanzhou, Peoples R China;[5]Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Endocrinol, Chengdu, Peoples R China

第一机构：Lanzhou Univ, Sch Clin Med 1, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Endocrinol, Chengdu, Peoples R China.

年份：2026

卷号：17

期号：3

起止页码：411

外文期刊名：JOURNAL OF DIABETES INVESTIGATION

收录：;Scopus(收录号：2-s2.0-105027874059);WOS:【SCI-EXPANDED(收录号:WOS:001664059800001)】；

基金：The study was supported by the Science and Technology Major Project, Gansu Province (project No: 22ZD6FA033).

语种：英文

外文关键词：Characteristics; Epidemiology; Type 1 diabetes

摘要：Objective To comprehensively analyze the characteristics of type 1 diabetes and compare the differences between childhood-onset and adult-onset groups.Methods Hospital records of patients with type 1 diabetes of all ages were collected from 18 hospitals across 14 prefectures in Northwest China between January 2016 and October 2023. Data included demographic characteristics, manifestation at onset, physical examination, laboratory tests, and management. Based on diagnosis status, participants were classified into newly diagnosed and previously diagnosed groups. Additionally, according to the age at onset, participants were further divided into childhood-onset and adult-onset groups.Results Among the 1,513 individuals with type 1 diabetes, the newly diagnosed group showed a younger median age of onset, lower mean body mass index, and better beta-cell function compared with the previously diagnosed group. Diabetic ketoacidosis at diagnosis was common, and the prevalence of chronic complications increased with disease duration. Most patients in both groups used multiple daily injections. Additionally, patients with childhood-onset type 1 diabetes were more likely to have diabetic ketoacidosis at diagnosis and had higher HbA1c levels at disease onset, lower BMI levels, and lower prevalence of complications compared with those with adult-onset diabetes.Conclusion This multicenter, hospital-based study provided an overview of the characteristics of patients with type 1 diabetes. These findings may contribute to a better understanding of type 1 diabetes and underscore the importance of long-term diabetic education and management.