文献类型：期刊文献

英文题名：Drug Repurposing: Research Progress of Niclosamide and Its Derivatives on Antibacterial Activity

作者：Liu, Zhihong[1,2];Liang, Xiaofang[1];Zhang, Yu[1];Deng, Wenbo[1];Wang, Yulin[3];Lu, Zhangping[2];Liu, Qianqian[2];Wei, Lianhua[2]

第一作者：柳振华;刘臻华;Liu, Zhihong

通信作者：Wei, LH[1]

机构：[1]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou, Gansu, Peoples R China;[2]Gansu Prov Hosp, Dept Clin Lab, Lanzhou, Gansu, Peoples R China;[3]Ningxia Med Univ, Yinchuan, Ningxia, Peoples R China

第一机构：甘肃中医药大学公共卫生学院

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Clin Lab, Lanzhou, Gansu, Peoples R China.

年份：2024

卷号：17

起止页码：4539

外文期刊名：INFECTION AND DRUG RESISTANCE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001338102600001)】；

基金：Acknowledgments This study was funded by the Intramural Research Fund Program of Gansu Provincial People's Hospital (no.22GSSYA-2) ; Gansu Province Health Sector Project (no.GZK-2012-17) .

语种：英文

外文关键词：antimicrobial resistance; multi-drug resistance; niclosamide; a derivative; drug repurposing

摘要：The development of antibiotic resistance complicates the treatment of infectious diseases and is a global public health threat. However, drug repurposing can address this resistance issue and reduce research and development costs. Niclosamide is a salicylanilide compound approved by the Food and Drug Administration (FDA), and it has been used clinically for treating parasitic infections for many years. Recent studies have shown that niclosamide can inhibit bacterial and fungus activity by affecting the quorum sensing system, biofilm formation, cell membrane potential, and other mechanisms. Here, we discuss recent advances in the antimicrobial applications of niclosamide and its derivatives to provide new perspectives in treating infectious diseases.