文献类型：期刊文献

中文题名：活血定眩丸的毒理学研究

英文题名：Study on Toxicology of HuoXueDingXuan Pill

作者：宋敏[1];徐乐勤[1];蒋宜伟[1];景明[1];蔺兴遥[1]

第一作者：宋敏

机构：[1]甘肃中医学院,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2008

卷号：19

期号：6

起止页码：1326

中文期刊名：时珍国医国药

外文期刊名：Lishizhen Medicine and Materia Medica Research

收录：北大核心:【北大核心2004】；CSCD:【CSCD_E2011_2012】；

基金：甘肃省教育厅科研项目(No.0606-03)

语种：中文

中文关键词：活血定眩丸;毒理学;急性毒性;长期毒性

外文关键词：HuoXueDingXuan Pill; Toxicology; Acute toxicity; Long - term toxicity

摘要：目的观察动物口服活血定眩丸的急性毒性和长期毒性反应。方法以最大浓度、最大体积的活血定眩丸灌服小鼠,测定l日最大给药量。以高、中、低3个剂量的活血定眩丸灌服大鼠连续6周,观察大鼠的生长发育、血液学、血液生化学、脏器系数、组织病理学变化及停药后2周上述指标的变化。结果小鼠2次/d灌服活血定眩丸的最大给药>148.8g生药/kg体重,此剂量相当于临床成人每日口服剂量0.224 2 g生药/kg体重的663倍。长期毒性实验显示,大鼠摄食量、活动、体重、血液学、生化指标检查、脏器重量系数、病理学检查均未见明显异常,与对照组相比均无明显差异。结论活血定眩丸的急性毒性和长期毒性实验均未见有明显毒性反应。
Objective To observe the acute toxicity of HuoXueDingXuan Pill （HXDX） on mice and its longterm toxicity on rats. Methods The maximum administration dosage（MAD） of HXDX was tested by gastric infusion of two times in mice. Three groups of rats were administered with repeated gastric infusion of HXDX for 6 weeks. Body weight, hematological and hematobiochemical parameters, coefficient and histomorphological figure of organs were examined in 6th week and 2 weeks after the cessation of HXDX. Results The maximum tolerance dose in a day was more than 148.8 g/kg（ crude drug） which was equivalent to 663 times of clinical daily dosage （0. 2242 g/kg）. There is no significant difference in food, behavior, weight, hematological and hematobiochemical parameters, coefficient and histomorphological figure of organs between the experimental and the control group. Conclusion Toxicity of the drug was not observed in acute or chronic toxicity tests.