文献类型：期刊文献

英文题名：Targeting the brain-gut-prostate axis in chronic prostatitis: mechanisms and therapeutics

作者：Song, Shiwei[1,2];Zhang, Chunlei[1];Zhang, Bin[1];Yin, Jinlong[2];Yu, Chang[2];Wang, Xuanrong[2];Wang, Qing[2];Ma, Fulin[2];Yang, Changfeng[2];Chang, Dehui[1]

第一作者：Song, Shiwei

通信作者：Chang, DH[1]

机构：[1]940th Hosp Joint Logist Support Force PLA, Dept Hyg Logist, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Sch Clin Med 1, Lanzhou, Peoples R China

第一机构：940th Hosp Joint Logist Support Force PLA, Dept Hyg Logist, Lanzhou, Peoples R China

通信机构：[1]corresponding author), 940th Hosp Joint Logist Support Force PLA, Dept Hyg Logist, Lanzhou, Peoples R China.

年份：2025

卷号：16

外文期刊名：FRONTIERS IN ENDOCRINOLOGY

收录：;Scopus(收录号：2-s2.0-105010938192);WOS:【SCI-EXPANDED(收录号:WOS:001530297900001)】；

基金：The author(s) declare that financial support was received for the research and/or publication of this article. This research was supported by the Gansu Provincial Departmental Scientific Research Project (2023KYLL205), the National Major Needs Cultivation Special Project (31920240072), the Gansu Provincial Natural Science Foundation (22JR5RA001, 22KYLL195, 23JRRA531), and the University-College Collaborative Innovation Key Project (HXLH-XTCX11). The project of Central Universities (31920240072); the Key Project of University-College Collaborative Innovation (HXLH-XTCX11); the Gansu Provincial Natural Science Foundation (22JR5RA001, 22KYLL195, 23JRRA531, 23JRRA001); the Lanzhou City Science and Technology Project (2023-2-63). The funders had no role in the design of the study, data collection, analysis, decision to publish, or preparation of the manuscript.

语种：英文

外文关键词：chronic prostatitis; gut microbiota; neuroimmune interactions; therapeutics; CP/CPPS

摘要：Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), a refractory urinary system disorder, is closely associated with dysregulation of the brain-gut-prostate axis. Emerging evidence highlights the pivotal role of gut microbiota dysbiosis and its bidirectional interactions with the neuroimmune system in CP/CPPS pathogenesis. This systematic review integrates perspectives from microbiomics, neuroimmunology, and metabolomics to propose a theoretical framework of the brain-gut-prostate axis and multi-dimensional therapeutic strategies targeting this axis. By transcending conventional localized anti-inflammatory approaches, these strategies aim to address clinical resistance and phenotypic heterogeneity. Mechanistic insights into microbiota-derived metabolites (e.g., short-chain fatty acids, SCFAs), neuroendocrine signaling (e.g., thyrotropin-releasing hormone, TRH), and immune crosstalk (e.g., Th17/Treg imbalance) are explored, alongside innovative therapies such as microbiome modulation, neural interventions, and immune regulation. This holistic paradigm not only provides new mechanistic insights but also offers promising avenues for personalized management and translational research in CP/CPPS, potentially overcoming current therapeutic bottlenecks.