文献类型：期刊文献

中文题名：生骨再造散对家兔骨折愈合影响的实验研究

英文题名：An experimental study of the effects of Shenggu Zaizao powder(生骨再造散)on fracture-healing of rabbits

作者：李红专[1];张晓刚[2];吴佳奇[2]

第一作者：李红专

机构：[1]甘肃省中医院骨科;[2]甘肃中医学院第二附属医院骨科

第一机构：甘肃省中医院骨科

年份：2005

卷号：18

期号：5

起止页码：272

中文期刊名：中国骨伤

外文期刊名：China Journal of Orthopaedics and Traumatology

收录：CSTPCD;;Scopus;PubMed

基金：甘肃省科技厅立项课题(编号:QS031C3320)

语种：中文

中文关键词：生骨再造散;实验研究;家兔;ALPase;显著性差异;血清碱性磷酸酶;组织形态学观察;促进骨折愈合;仙灵骨葆;生物力学测试;生物力学性能;骨折愈合过程;对照组;0.05;实验组;治疗机制;灌胃给药;生理盐水;骨折修复;不同程度;愈合质量

外文关键词：Shenggu Zaizao powder(生骨再造散); Fracture healing; Alkaline phosphatase; Biomechanics; Chinese patent drugs

摘要：目的:检验生骨再造散促进骨折愈合的疗效,并探讨其治疗机制。方法:选用42只健康家兔,做双侧桡骨3mm缺损的骨折,随机分为实验组、药物对照组(仙灵骨葆)和空白对照组,分别以生骨再造散、仙灵骨葆和生理盐水灌胃给药,术后第1、2、3、4周采血,检测血清碱性磷酸酶(ALPase)。术后第14天和第31天分批处死兔子取桡骨标本,摄X线片,作生物力学测试和骨痂组织形态学观察。结果:骨折后第14天和第31天,实验组的X线片计分显示骨折修复优于空白对照组,生物力学性能和骨痂组织形态学均显著优于空白对照组(P<0.05,P<0.01),与药物对照组无显著性差异。ALPase在第1周和第4周各组间无显著性差异;第2周3组ALPase都不同程度升高,实验组和药物对照组均明显高于空白对照组,但实验组和药物对照组无差异;第3周实验组和药物对照组的ALPase均明显高于空白对照组,且实验组和药物对照组也有显著性差异(P<0.05,P<0.01)。结论:生骨再造散能缩短骨折愈合过程所需时间,提高骨折愈合质量,与仙灵骨葆疗效相似。
Objective:To verify the therapeutic effect of Shenggu Zaizao powder(SGZZP)on fracture healing and explore its probable mechanism.Methods:Forty-two rabbits were selected to make radial fractures at both sides with 3 mm defect,and divided randomly into three groups:experimental group,drug control group(Xianling Gubao(仙灵骨葆,XLGB),and blank control group.They were fed orally with SGZZP,XLGB and normal saline respectively.Their blood was drawn on the 1st,2nd,3rd,4th week after fracture,and were examined for alkaline phosphatase(ALPase)in serum.They were put to death on the 14th and 31st day after fracture in batches,and the radius specimens were taken out.The indices for observation included X-ray films,biomechanical tests and callus histomorphology.Results:On the 14th and 31st day after operation,the X-ray films,the biomechanical properties and histomorphology suggested that the fracture healing of the test group were better than that of the blank control group(P<0.05 or P<0.01),and were not different to the drug control's.On the 1st and 4th week after operation,the ALPase level in the three groups was not different.On the 2nd week,three groups were characterized by an increase in the ALPase level,and the test and the drug control group were significantly higher than those in the blank control group,but the former two were not different.On the 3rd week,the ALPase level of the test and the drug control group was significantly higher than those in the blank control group,while the test group's were significantly higher than that of the drug control group.Conclusion:SGZZP is able to shorten the time of the fracture-healing period,improve the fracture healing quality and are similar to the therapeutic effect of XLGB.