文献类型：期刊文献

英文题名：A partial peroxisome proliferator-activated receptor gamma agonist isolated from the roots of Euphorbia sikkimensis

作者：He, Liping[1];Yuchen, Daili[2];Zhang, Shangzhi[1];Hui, Yangyang[2];Wei, Namei[2];He, Yangqing[2]

第一作者：贺莉萍

通信作者：He, YQ[1]

机构：[1]Gansu Univ Chinese Med, Dept Pharm, Dingxi, Peoples R China;[2]Xian Univ Technol, Dept Appl Chem, Xian, Peoples R China

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

通信机构：[1]corresponding author), Xian Univ Technol, Dept Appl Chem, Xian, Peoples R China.

年份：0

外文期刊名：NATURAL PRODUCT RESEARCH

收录：;Scopus(收录号：2-s2.0-85149004046);WOS:【SCI-EXPANDED(收录号:WOS:000940275000001)】；

基金：This work was supported by the Key Research and Development Program of Gansu Province (21YF5FJ193 and 21YF5FJ195), the Key Scientific and Technological Research projects of Dingxi (DX2021AZ05 and DX2022AZ04) and Shaanxi Key Laboratory of Phytochemistry (SJKFKT-001).

语种：英文

外文关键词：Euphorbiaceae; Euphorbia sikkimensis; terpenes; ent-atisane diterpene; ent-kaurane diterpene; PPAR gamma

摘要：Chemical constituents of the Euphorbia sikkimensis roots was investigated and twelve known compounds were isolated, including three ent-atisane diterpenes: ent-(13S)-hydroxyatis-16-ene-3,14-dione (1), ent-(5 beta,8 alpha,9 beta,10 alpha,11 alpha,12 alpha)-11-hydroxyatis-16-ene-3,14-dione (2), ent-atisane-3-oxo-16 alpha,17-diol (3); two kaurene diterpenes: ent-kaurane-3-oxo-16 alpha,17-diol (4), ent-kaurane-3-oxo-16 beta,17-diol (5); one lathyane diterpene of latilagascene B (6); two flavonoids: quercetin (7), luteolin (8); one lignin d-pinoresinol (9); one coumarin scopoletin (10); together with ethyl gallate (11), p-hydroxybenzaldehyde (12). Their structures were identified based on the extensive spectroscopic analysis in comparison with the literature data. Compounds 1, 2, 4, 6 and 9 were isolated from Euphorbia sikkimensis for the first time. The agonistic activity of peroxisome proliferator-activated receptor gamma (PPAR gamma) for compounds 1, 7, 8, 9 and 11 was evaluated. Compound 1 exhibited moderate agonistic activity for PPAR gamma receptor with relative fluorescence intensity of 10.19 at 30.0 mu M, in comparison with that of the positive control of rosiglitazone (28.50 at 2.0 mu M).