文献类型：期刊文献

英文题名：Five undescribed plant-derived bisphenols from Artemisia capillaris aerial parts: Structure elucidation, anti-hepatoma activities and plausible biogenetic pathway

作者：Ge, Lanlan[1,2,3,4,5];Xie, Qiujie[1,2,3];Wei, Xiaofang[1,2,3,6];Li, Yangfang[1,2,3];Shen, Wanying[1,2,3,6];Hu, Yunguang[7];Yao, Jie[1,2,3];Wang, Shuling[8];Du, Xiao[8,9];Zeng, Xiaobin[1,2,3,4,5,10]

第一作者：Ge, Lanlan

通信作者：Zeng, XB[1];Zeng, XB[2];Du, X[3]

机构：[1]Jinan Univ, Shenzhen Peoples Hosp, Ctr Lab Longhua Branch, Clin Med Coll 2, Shenzhen 518020, Guangdong, Peoples R China;[2]Jinan Univ, Shenzhen Peoples Hosp, Dept Infect Dis, Clin Med Coll 2, Shenzhen 518020, Guangdong, Peoples R China;[3]Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China;[4]Jinan Univ, Shenzhen Peoples Hosp, Longhua Branch, Clin Med Coll 2,Dept Pathol, Shenzhen 518120, Guangdong, Peoples R China;[5]Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518120, Guangdong, Peoples R China;[6]Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Gansu, Peoples R China;[7]Guangdong Yifang Pharmaceut Co Ltd, Foshan 528241, Guangdong, Peoples R China;[8]Hangzhou Normal Univ, Sch Med, Coll Pharm, Hangzhou 311121, Zhejiang, Peoples R China;[9]China Resources Sanjiu Med & Pharmaceut Co Ltd, Shenzhen 518110, Guangdong, Peoples R China;[10]Shenzhen Univ, Guangdong Prov Key Lab Reg Immun & Dis, Med Sch, Shenzhen 518037, Guangdong, Peoples R China

第一机构：Jinan Univ, Shenzhen Peoples Hosp, Ctr Lab Longhua Branch, Clin Med Coll 2, Shenzhen 518020, Guangdong, Peoples R China

通信机构：[1]corresponding author), Jinan Univ, Shenzhen Peoples Hosp, Ctr Lab Longhua Branch, Clin Med Coll 2, Shenzhen 518020, Guangdong, Peoples R China;[2]corresponding author), Jinan Univ, Shenzhen Peoples Hosp, Dept Infect Dis, Clin Med Coll 2, Shenzhen 518020, Guangdong, Peoples R China;[3]corresponding author), Hangzhou Normal Univ, Sch Med, Coll Pharm, Hangzhou 311121, Zhejiang, Peoples R China.

年份：2023

卷号：16

期号：4

外文期刊名：ARABIAN JOURNAL OF CHEMISTRY

收录：;EI(收录号：20230413440253);Scopus(收录号：2-s2.0-85146608388);WOS:【SCI-EXPANDED(收录号:WOS:000963245600001)】；

基金：This work was supported by National Natural Science Foundation of China (81503221, and 81903760) , Natural Science Foundation of Guangdong Province (2017A030313659, and 2021A1515220185) , and Shenzhen Fundamental Research and Discipline Layout Project (JCYJ20170413093108233, JCYJ20190806151816859, JCYJ20190806153401647 and JCYJ20220818102609021) .

语种：英文

外文关键词：Artemisia capillaris; Bisphenols; Structure elucidation; Plausible biogenetic path; Anti-hepatoma activity; Plausible biogenetic path- way

摘要：Yin-Chen, which belongs to the Asteraceae family and the genus Artemisia, is among the most abundantly used traditional medicines in China for the treatment of hepatitis and bilious disorder. Herein, five undescribed plant-derived bisphenols, capillarisenols A-E (13, 15, 25, 29, 31), and one undescribed phenolic compound (32), together with 32 known phenolic compounds (1-12, 14, 16-24, 26-28, 30, 33-38), were isolated and identified based on spectroscopic evidence from aerial parts of Artemisia capillaris Thunb. Capillarisenols A-E are the type of bisphenols firstly isolated from this plant. The plausible biogenetic pathway of new compounds was also pro-posed. In addition, the potential anti-hepatoma effects on Huh7 and HepG2 cell lines of all isolated compounds were evaluated in vitro. Capillarisenol C (25) showed significant anti-hepatoma activity in Huh7 and HepG 2 cells, with IC50 values of 4.96 and 8.58 mu M, better than the positive control drug (Lenvatinib). This study provided phytochemical evidence for further development and utili-sation of A. capillaris in health products.