文献类型：期刊文献

中文题名：岷当归有效成分对高同型半胱氨酸血症致兔动脉粥样硬化的影响

英文题名：Effects of the Effective Constituents of Min Angelicae Sinensis Radix on Hyperhomocysteinemia Induced Rabbit Atherosclerotic Lesions

作者：王晓萍[1];周明旺[1];康开彪[2];颜春鲁[3];李妍怡[1]

第一作者：王晓萍

机构：[1]甘肃省中医院,甘肃兰州730050;[2]甘肃省中医药研究院,甘肃兰州730050;[3]甘肃中医药大学,甘肃兰州730000

第一机构：甘肃省中医院,甘肃兰州730050

年份：2018

卷号：25

期号：2

起止页码：51

中文期刊名：中国中医药信息杂志

外文期刊名：Chinese Journal of Information on Traditional Chinese Medicine

收录：CSTPCD;;CSCD:【CSCD_E2017_2018】；

基金：甘肃省自然科学研究基金计划项目(1208RJZA187);甘肃省高等学校科研项目(2013A-086)

语种：中文

中文关键词：高同型半胱氨酸血症;动脉粥样硬化;当归挥发油;当归多糖;阿魏酸;兔

外文关键词：hyperhomocysteinemia; atherosclerosis; Angelicae Sinensis Radix volatile oil; Angelicae Sinensis Radix polysaccharide; ferulic acid; rabbits

摘要：目的观察岷当归3种有效成分(当归挥发油、当归多糖、阿魏酸)对高同型半胱氨酸血症致兔动脉粥样硬化(AS)的影响,探讨其作用机制。方法日本大耳白兔48只,随机分为正常组、模型组、当归挥发油组、当归多糖组、阿魏酸组和叶酸维生素组,每组8只。采用DL-蛋氨酸皮下注射法建立高同型半胱氨酸血症兔模型,造模8周后各给药组给予相应药物灌胃,12周后检测各组兔血清同型半胱氨酸(Hcy)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)水平,观察兔腹主动脉病理变化。结果模型组较正常组Hcy水平明显升高(P<0.05);当归挥发油组、阿魏酸组、叶酸维生素组Hcy水平较模型组明显降低(P<0.05);当归挥发油组、阿魏酸组TC、TG、LDL-C水平较模型组明显降低(P<0.05)。腹主动脉组织学检查显示,模型组AS征象明显,叶酸维生素组、当归挥发油组、阿魏酸组病变程度较模型组减轻。结论岷当归有效成分当归挥发油和阿魏酸能减轻模型兔血管内皮的损伤,对高同型半胱氨酸血症致兔AS病变有防治作用。
Objective To observe the effects of three effective constituents of Min Angelicae Sinensis Radix on hyperhomocysteinemia （HHcy） induced rabbit atherosclerotic lesions （AS）. Methods Forty eight Japanese big ear rabbits were randomly divided into normal group, model group, Angelicae Sinensis Radix volatile oil group, Angelicae Sinensis Radix polysaccharide group, ferulic acid group and folic acid group, with 8 rabbits in each group. The HHcy rabbit model induced AS was duplicated by injected DL-methionine. After 8 weeks, each medication group was given relevant medicine for gavage. After 12 weeks, Hcy, TC, TG, HDL-C and LDL-C level in serum were detected, and abdominal aorta vascular ultrasound were observed. Results The model group was higher than the normal group in the level of Hcy （P〈0.05）. Compared with the model group, the levels of Hcy in Angelicae Sinensis Radix volatileoil group, the ferulic acid group and the folic acid group decreased （P〈0.05）. Compared with the model group, the levels of TC, TG and LDL-C in AngelicaeSinensis Radix volatile oil group, ferulic acid group and folic acid group decreased （P〈0.05）. Abdominal aorta ultrasonography showed that the degree of AS was significantly attenuated in folic acid group, Angelicae Sinensis Radix volatile oil group and ferulic acid group. Conclusion Angelicae Sinensis Radix volatile oil and ferulic acid in Min Angelicae Sinensis Radix can reduce the harm to endothelium and can prevent and treat HHcy caused by rabbit AS.