文献类型：期刊文献

英文题名：Prospective cohort study on the clinical significance of interferon-γ, D-dimer, LDH, and CRP tests in children with severe mycoplasma pneumonia

作者：Zhang, Yu-xiang[1];Li, Yang[1];Wang, Yong[1];Ren, You-feng[1];Yang, Yue[1];Qi, Jing[1];Yang, Hui[2];Liang, Xuan[2];Zhang, Rong-fang[2]

第一作者：张芸霞;张艳霞;张云香

通信作者：Zhang, RF[1]

机构：[1]Gansu Univ Chinese Med, Gansu Maternal & Child Hlth Hosp, Clin Med Coll 1, Dept Allergy, Lanzhou, Peoples R China;[2]Gansu Prov Matern & Child Care Hosp, Dept Allergy, 35 Chengguan Dist, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Matern & Child Care Hosp, Dept Allergy, 35 Chengguan Dist, Lanzhou, Gansu, Peoples R China.

年份：2024

卷号：103

期号：41

起止页码：e39665

外文期刊名：MEDICINE

收录：;Scopus(收录号：2-s2.0-85207461767);WOS:【SCI-EXPANDED(收录号:WOS:001338585900069)】；

语种：英文

外文关键词：C-reactive protein; D-dimer; interferon-gamma; lactate dehydrogenase; pediatrics; severe Mycoplasma pneumoniae pneumonia

摘要：Background: Mycoplasma pneumoniae is a significant cause of respiratory infections in children, often leading to severe pneumonia. This study aimed to assess the clinical relevance of interferon-gamma (interferon-gamma), D-dimer, lactate dehydrogenase (LDH), and C-reactive protein (CRP) as biomarkers in the severity of mycoplasma pneumonia in pediatric patients. Methods: In this prospective study, 203 pediatric patients with mycoplasma pneumonia were classified into mild (123 patients) and severe (80 patients) groups. Biomarkers including interferon-gamma, D-dimer, LDH, and CRP were measured and analyzed. Statistical methods employed included Pearson and Spearman correlation analyses, logistic regression, and receiver operating characteristic curve analysis. Results: The severe group exhibited significantly higher median and interquartile ranges for interferon-gamma, D-dimer, LDH, and CRP compared to the mild group. Logistic regression identified IL-10, IL-6, interferon-gamma, tumor necrosis factor-alpha, D-dimer, and LDH as independent predictors of severity, with the model achieving 92% accuracy. Receiver operating characteristic curve analysis showed optimal diagnostic efficacy for interferon-gamma, D-dimer, and LDH, with the best threshold values being 8.11, 0.64, and 379, respectively. A significant positive correlation was observed between IL-6 and LDH, as well as between interferon-gamma and D-dimer. Conclusion: This study showed that interferon-gamma >8.11, D-dimer >0.64, and LDH >379 have an important role in the assessment of severe mycoplasma pneumonia.