文献类型：期刊文献

英文题名：Radix Bupleuri: A Review of Traditional Uses, Botany, Phytochemistry, Pharmacology, and Toxicology

作者：Yang, Fude[1];Dong, Xiaoxv[2];Yin, Xingbin[2];Wang, Wenping[2];You, Longtai[2];Ni, Jian[1,2]

第一作者：杨扶德

通信作者：Ni, J[1];Ni, J[2]

机构：[1]Gansu Univ Chinese Med, Lanzhou 730000, Peoples R China;[2]Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Lanzhou 730000, Peoples R China;[2]corresponding author), Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China.|[10735]甘肃中医药大学;

年份：2017

卷号：2017

外文期刊名：BIOMED RESEARCH INTERNATIONAL

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000402287200001)】；

基金：This work was financially supported by the Collaborative Innovation Construction Plan of Beijing University of Chinese Medicine (no. 2013-XTCX-03).

语种：英文

摘要：Radix Bupleuri (Chaihu) has been used as a traditional medicine for more than 2000 years in China, Japan, Korea, and other Asian countries. Phytochemical studies demonstrated that this plant contains essential oils, triterpenoid saponins, polyacetylenes, flavonoids, lignans, fatty acids, and sterols. Crude extracts and pure compounds isolated from Radix Bupleuri exhibited various biological activities, such as anti-inflammatory, anticancer, antipyretic, antimicrobial, antiviral, hepatoprotective, neuroprotective, and immunomodulatory effects. However, Radix Bupleuri could also lead to hepatotoxicity, particularly in high doses and with long-termuse. Pharmacokinetic studies have demonstrated that the major bioactive compounds (saikosaponins a, b2, c, and d) were absorbed rapidly in rats after oral administration of the extract of Radix Bupleuri. This review aims to comprehensively summarize the traditional uses, botany, phytochemistry, pharmacology, toxicology, and pharmacokinetics of Radix Bupleuri reported to date with an emphasis on its biological properties and mechanisms of action.