文献类型：期刊文献

中文题名：抽动障碍动物模型的研究进展及在中医药研究中的应用

英文题名：Research Progress of Animal Model of Tic Disorder and Its Application in Traditional Chinese Medicine

作者：冯鹏[1];史正刚[1];杨欢[1];孙治前[1];罗文珍[1]

第一作者：冯鹏

机构：[1]甘肃中医药大学,兰州730000

第一机构：甘肃中医药大学

年份：2020

卷号：26

期号：15

起止页码：207

中文期刊名：中国实验方剂学杂志

外文期刊名：Chinese Journal of Experimental Traditional Medical Formulae

收录：CSTPCD;;北大核心:【北大核心2017】；CSCD:【CSCD2019_2020】；

基金：国家自然科学基金项目(81960886)。

语种：中文

中文关键词：抽动障碍;动物模型;中医药;研究进展

外文关键词：tic disorder;animal model;traditional Chinese medicine;research progress

摘要：抽动障碍(TD)是以一种或多种运动和/或发声性抽动为主要症状的神经发育障碍性疾病,给患儿在学习、生活上带来了诸多不便,对患儿性格塑造的影响尤为深远。TD的发病机制至今尚未完全明确,主要与神经递质释放紊乱、神经免疫、遗传、微量元素失衡、饮食等因素有关。西药治疗TD效果虽然明显但都有严重的副作用,相比之下,中医药治疗TD具有副作用小、疗效确切且持久的优势,得到了患儿及家长的广泛认可。为探明TD的发病机制以及中药复方治疗TD的具体作用机制,众多学者进行了大量深入的动物实验研究,取得了一定的成果,但也暴露出一些缺陷,例如造模法方法单一,未能考虑到TD的其他发病机制,也未能结合中医的具体证型进行针对性的造模,没有体现出中医辨证论治的特点。该文综述常见动物模型的建模方法以及优缺点的的比较,并回顾总结中药复方对TD动物模型干预前后行为学、相关指标的变化,为今后进行动物实验研究时有针对性的选择动物模型提供参考。
Tic disorder(TD)is a neurodevelopmental disorder,with one or more motor and/or vocal disorders as the main symptoms. It brings many inconveniences to children’s learning and life,and has a profound impact on children’s character building. The pathogenesis of TD is mainly correlated with neurotransmitter release disorder,neuroimmune,genetic,trace element imbalance,diet and other factors,but has not been completely clear up to now. Western Medicine has obvious effects on TD,but with serious side effects. Compared with western medicine,traditional Chinese medicine(TCM)has the advantages of low adverse reactions and definite and lasting effect,and thus has been widely recognized by children and their families. In order to explore the pathogenesis of TD and the specific mechanism of TCM in the treatment of TD,many scholars have carried out a large number of in-depth animal experiments and made some achievements,but also exposed some defects,such as the single modeling method,failed to take into account other pathogenesis of TD,failure to combine the specific syndromes of TCM for targeted modeling,and failure to reflect the dialectic of TCM on the characteristics of governance. This paper reviews the modeling methods of common animal models,the comparison of advantages and disadvantages,and the changes of behavioral and biochemical indicators before and after the intervention with TCM compounds on TD animal models,so as to provide reference for the selection of animal models in future animal experimental research.