文献类型：期刊文献

中文题名：中药单体成分调控氧化应激防治消化道肿瘤的研究现状

英文题名：Research progress on the regulation of oxidative stress by single components of traditional chinese medicine in the prevention and treatment of gastrointestinal tumors

作者：高永泽[1,2];张玉静[3];贾了婵[3];尉戎戎[4];苏海霞[5];赫子娇[1];付兆媛[1,2];张进丽[1]

第一作者：高永泽

机构：[1]甘肃中医药大学附属医院,甘肃兰州730020;[2]甘肃省中西医结合消化病临床医学研究中心,甘肃兰州730000;[3]甘肃中医药大学,甘肃兰州730000;[4]甘谷县人民医院消化内科,甘肃天水741200;[5]兰州市第二人民医院肝病科,甘肃兰州730000

第一机构：甘肃中医药大学第二附属医院

年份：2026

卷号：42

期号：3

起止页码：412

中文期刊名：中国临床药理学杂志

外文期刊名：The Chinese Journal of Clinical Pharmacology

收录：;北大核心:【北大核心2023】；

基金：国家重点研发计划基金资助项目(2025ZD0551500);甘肃省自然科学基金资助项目(25JRRA238);甘肃省卫生健康行业科研计划基金资助项目(GSWSQN2022-03);甘肃省中西医结合消化病临床医学研究中心基金资助项目(23YFFA0054);甘肃省中西医结合肿瘤临床医学研究中心开放基金资助项目(zlzx2021-4);中西医结合学科2023年度“双一流”科研重点项目暨甘肃省中医药防治慢性疾病重点实验室开放课题基金资助项目(GSSYLXM-05);2022年陇原青年创新创业人才基金资助项目。

语种：中文

中文关键词：中药单体;氧化应激;消化道肿瘤

外文关键词：single-component Chinese herbal medicine;oxidative stress;gastrointestinal tumors

摘要：消化道肿瘤作为临床上常见且危害严重的恶性肿瘤,其发生发展与氧化应激密切相关。氧化应激通过诱导细胞内活性氧(ROS)水平失衡,促进肿瘤细胞增殖、侵袭及耐药性形成,已成为当前肿瘤防治研究的重要靶点。近年来,中药单体成分因其结构明确、作用多样以及多靶点调控的特性,在调节氧化应激方面展现出显著潜力。本文系统综述了多种中药单体成分通过抗氧化机制抑制消化道肿瘤细胞增殖与迁移、诱导细胞凋亡,并调节肿瘤微环境等方面的最新研究进展,重点分析了其中涉及的关键信号通路和分子靶点,如核因子E2相关因子2(Nrf2)、丝裂原活化蛋白激酶(MAPK)及核因子κB(NF-κB)等。结合现有实验证据及部分临床数据,进一步揭示了中药单体在消化道肿瘤防治中的潜在应用价值及当前研究所面临的挑战,以期为该领域的基础研究与新药研发提供理论依据和方向参考。
Gastrointestinal tumors,as clinically prevalent and highly malignant cancers,are closely associated with oxidative stress in their development.By inducing imbalances in intracellular reactive oxygen species(ROS)levels,oxidative stress promotes tumor cell proliferation,invasion,and drug resistance,making it a key target in contemporary cancer prevention and treatment research.In recent years,individual components of traditional Chinese medicine(TCM)have demonstrated significant potential in regulating oxidative stress due to their well-defined structures,diverse actions,and multi-target regulatory properties.This systematic review summarizes recent advances in how various TCM monomeric components inhibit gastrointestinal tumor cell proliferation and migration,induce apoptosis,and modulate the tumor microenvironment through antioxidant mechanisms.It focuses on analyzing key signaling pathways and molecular targets involved,such as nuclear factor E2-related factor 2(Nrf2),mitogen-activated protein kinase(MAPK),and nuclear factor kappa-B(NF-κB).Integrating existing experimental evidence and partial clinical data,this review further reveals the potential application value of TCM monomers in the prevention and treatment of gastrointestinal tumors,while identifying current research challenges.It aims to provide theoretical foundations and directional references for basic research and new drug development in this field.