文献类型：期刊文献

英文题名：Neuropeptide S Displays as a Key Neuromodulator in Olfactory Spatial Memory

作者：Wang, Can[1,2,3,4];Xin, Le[1,2,3,4,5];Cai, Chen-Chen[1,2,3,4];Cong, Chao-Yu[1,2,3,4];Xie, Jun-Fan[1,2,3,4];Kong, Xiang-Pan[1,2,3,4,6];Dong, Chao-Yu[1,2,3,4,7];Li, Jing[1,2,3,4,8,9,10];Cui, Guang-Fu[1,2,3,4];Chen, Hai-Lin[1,2,3,4];Ren, Yan-Li[1,2,3,4];Shao, Yu-Feng[1,2,3,4];Hou, Yi-Ping[1,2,3,4]

第一作者：Wang, Can

通信作者：Shao, YF[1]

机构：[1]Lanzhou Univ, Sch Basic Med Sci, Dept Neurosci, Key Lab Preclin Study New Drugs Gansu Prov, 199 Donggang Xi Rd, Lanzhou 730000, Peoples R China;[2]Lanzhou Univ, Sch Basic Med Sci, Dept Anat, Key Lab Preclin Study New Drugs Gansu Prov, 199 Donggang Xi Rd, Lanzhou 730000, Peoples R China;[3]Lanzhou Univ, Sch Basic Med Sci, Dept Histol, Key Lab Preclin Study New Drugs Gansu Prov, 199 Donggang Xi Rd, Lanzhou 730000, Peoples R China;[4]Lanzhou Univ, Sch Basic Med Sci, Dept Embryol, Key Lab Preclin Study New Drugs Gansu Prov, 199 Donggang Xi Rd, Lanzhou 730000, Peoples R China;[5]Anshan Cent Hosp, Lishan Hosp, Dept Anesthesiol, 32 Shuangshan Rd, Anshan 114032, Peoples R China;[6]Hunan Normal Univ, Sch Med, Dept Human Anat, 371 Tongzipo Rd, Changsha 410013, Peoples R China;[7]Third Peoples Hosp Yunnan Prov, Dept Gynaecol, 292 Beijing Rd, Kunming, Yunnan, Peoples R China;[8]Gansu Univ Chinese Med, Sch Basic Med Sci, Dept Anat, 35 Dingxi Dong Rd, Lanzhou 730000, Peoples R China;[9]Gansu Univ Chinese Med, Sch Basic Med Sci, Dept Histol, 35 Dingxi Dong Rd, Lanzhou 730000, Peoples R China;[10]Gansu Univ Chinese Med, Sch Basic Med Sci, Dept Embryol, 35 Dingxi Dong Rd, Lanzhou 730000, Peoples R China

第一机构：Lanzhou Univ, Sch Basic Med Sci, Dept Neurosci, Key Lab Preclin Study New Drugs Gansu Prov, 199 Donggang Xi Rd, Lanzhou 730000, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Sch Basic Med Sci, Dept Neurosci, 199 Donggang Xi Rd, Lanzhou 730000, Peoples R China.

年份：2020

卷号：45

期号：3

起止页码：195

外文期刊名：CHEMICAL SENSES

收录：;Scopus(收录号：2-s2.0-85083906567);WOS:【SCI-EXPANDED(收录号:WOS:000537371000003)】；

基金：This work was supported by the National Natural Science Foundation of China (81771426, 81471347, 81171254, and 81071076 to Y.P.H.; 31872770 and 31500853 to Y.F.S.) and the Fundamental Research Funds for the Central University (lzujbky-2015-277, lzujbky-2017-135 and lzujbky-2019-cd03 to Y.F.S. and lzujbky-2018-25 to J.F.X.).

语种：英文

外文关键词：antagonist; c-Fos; neuropeptide S; neuropeptide S receptor; olfactory spatial memory

摘要：Neuropeptide S (NPS) is an endogenous peptide recently recognized to be presented in the brainstem and believed to play an important role in maintaining memory. The deletion of NPS or NPS receptor (NPSR) in mice shows a deficit in memory formation. Our recent studies have demonstrated that central administration of NPS facilitates olfactory function and ameliorates olfactory spatial memory impairment induced by muscarinic cholinergic receptor antagonist and N-methyl-(D)-aspartate receptor antagonist. However, it remains to be determined if endogenous NPS is an indispensable neuromodulator in the control of the olfactory spatial memory. In this study, we examined the effects of NPSR peptidergic antagonist [D-Val(5)]NPS (10 and 20 nmol, intracerebroventricular) and nonpeptidergic antagonist SHA 68 (10 and 50 mg/kg, intraperitoneal) on the olfactory spatial memory using computer-assisted 4-hole-board olfactory spatial memory test in mice. Furthermore, immunofluorescence was employed to identify the distributions of c-Fos and NPSR immunoreactive (-ir) neurons in olfactory system and hippocampal formation known to closely relate to the olfactory spatial memory. [D-Val(5)]NPS dosing at 20 nmol and SHA 68 dosing at 50 mg/kg significantly decreased the number of visits to the 2 odorants interchanged spatially, switched odorants, in recall trial, and simultaneously reduced the percentage of Fos-ir in NPSR-ir neurons, which were densely distributed in the anterior olfactory nucleus, piriform cortex, subiculum, presubiculum, and parasubiculum. These findings suggest that endogenous NPS is a key neuromodulator in olfactory spatial memory.