文献类型：期刊文献

英文题名：The Application of Prostate Specific Membrane Antigen in the Diagnosis and Treatment of Prostate Cancer: Status and Challenge

作者：Zeng, Tongwei[1];Xie, Yongqiang[1];Chai, Keqiang[1];Sang, Hui[1]

第一作者：Zeng, Tongwei

通信作者：Chai, KQ[1];Sang, H[1]

机构：[1]Gansu Univ Tradit Chinese Med, Affiliated Hosp 3, Dept Urol, 222 Silong Rd, Baiyin, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Affiliated Hosp 3, Dept Urol, 222 Silong Rd, Baiyin, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2024

卷号：17

起止页码：991

外文期刊名：ONCOTARGETS AND THERAPY

收录：;Scopus(收录号：2-s2.0-85210235796);WOS:【SCI-EXPANDED(收录号:WOS:001356434700001)】；

基金：This work was supported by Baiyin Science and Technology Plan Project (Clinical Application research on screening of Prostate cancer in Baiyin Area: 2022-3-6Y) and Baiyin First People's Hospital Science and Technology Plan Project (2019YK-08) .

语种：英文

外文关键词：prostate cancer; PSMA; PET; radioligand therapy; CAR-T; DCs vaccine

摘要：In recent years, the incidence of prostate cancer has been increasing globally. Early stage of the disease can obtain a better clinical prognosis from surgery and endocrine therapy. The progression of advanced stage varies significantly between individuals, with some patients developing metastatic castration-resistant prostate cancer after standardized treatment. Therefore, staging of prostate cancer by accurate imaging is particularly important for the clinical management of patients. Simultaneously, the development of targeted therapy is also urgent for the treatment of advanced prostate cancer. Prostate specific membrane antigen as a prostate specific target has been widely used in the diagnosis and treatment of prostate cancer. This review summarizes the latest research progress of targeted prostate specific membrane antigen in the diagnosis and treatment of prostate cancer in detail, analyzes their value and challenges.