文献类型：期刊文献

中文题名：中药有效成分干预Nrf2信号通路防治糖尿病视网膜病变研究进展

英文题名：Progress in research on the prevention and treatment of diabetic retinopathy by the intervention of the nuclear red blood cell related factor 2 signaling pathway with effective components of traditional Chinese medicine

作者：陈一新[1];李辰[1];宋宾[1];左利平[1];刘建军[2];梁陆敏[1];南瑞雄[1];王家浩[1];潘李斌[1];王景蓉[3]

第一作者：陈一新

机构：[1]兰州市第一人民医院眼科,甘肃省兰州市730000;[2]甘肃中医药大学附属医院,甘肃省兰州市730000;[3]甘肃中医药大学第一临床医学院,甘肃省兰州市730000

第一机构：兰州市第一人民医院眼科,甘肃省兰州市730000

年份：2025

卷号：45

期号：8

起止页码：667

中文期刊名：眼科新进展

外文期刊名：Recent Advances in Ophthalmology

收录：;北大核心:【北大核心2023】；

基金：张晓刚全国名老中医药专家传承工作室建设项目(编号:国中医药人教函[2022]75号);兰州市城关区科技计划项目(编号:001042001);兰州市城关区科技计划项目(编号:2020-2-2-7);兰州市科技局社会发展科技项目(编号:2023-ZD-144)。

语种：中文

中文关键词：糖尿病;糖尿病视网膜病变;核红细胞相关因子2信号通路;中药

外文关键词：diabetes mellitus;diabetic retinopathy;nuclear red blood cell related factor 2 signaling pathway;traditional Chinese medicine

摘要：糖尿病视网膜病变(DR)是一种因糖尿病(DM)长期影响而发生的微血管病变,是全球视力障碍和失明的主要原因之一,其典型特征包括微动脉瘤、硬性渗出物、黄斑水肿(DME)和新生血管等,发病机制多种多样,根源在于氧化应激和晚期糖基化终产物。核红细胞相关因子2 (Nrf2)信号通路在预防各种疾病中起着重要作用。高血糖是DM的特征之一,它会激活线粒体中活性氧的生成。最终,这些氧化应激因子通过激活核转录因子κB通路成为各种DM合并症的主要诱因,而该通路会诱导促炎细胞因子的转录增加,包括肿瘤坏死因子-α、转化生长因子-β和白细胞介素1。中药的有效成分具有显著的抗氧化、抗炎、抗凋亡,并能促进血管生成等药理作用,可通过多种机制阻断DR进展。本文综述了中药靶向Nrf2信号通路防治DR的研究现状,以期指导临床和科学研究。
Diabetic retinopathy(DR)is a kind of microvascular disease caused by the long-term influence of diabetes mellitus(DM),and it is one of the main cause of global visual impairment and blindness.Its typical characteristics include microaneurysms,hard exudates,macular edema(DME)and neovascularization.Its pathogenesis is diverse,and the root cause is oxidative stress and advanced glycosylation end products.The nuclear red blood cell related factor 2(Nrf2)signaling pathway plays an important role in preventing various diseases.As one of the characteristics of DM,hyperglycemia will activate the generation of reactive oxygen species(ROS)in mitochondria.These oxidative stress factors activate the nuclear transcription factorκB pathway,becoming the main inducement of various complications of DM.This pathway will induce increased transcription of proinflammatory cytokines,including tumor necrosis factor-alpha,transforming growth factor-beta and interleukin-1.The active ingredients of traditional Chinese medicine have significant antioxidant,anti-inflammatory,anti-apoptotic and angiogenesis-promoting effects,and can block the progression of DR through various mechanisms.In this article,the research status of traditional Chinese medicine targeting the Nrf2 signaling pathway in the prevention and treatment of DR is reviewed to guide clinical and scientific research.