文献类型：期刊文献

中文题名：线粒体功能紊乱在代谢相关脂肪性肝病中的作用机制及中医药干预研究现状

英文题名：Mechanism of action of mitochondrial dysfunction in metabolic associated fatty liver disease and the current status of research on traditional Chinese medicine

作者：王丹[1];张金雪[1];苏李宁[1];李红梅[1];徐冰蕊[1];李亚静[2];赖学倩[3];刘俊宏[2]

第一作者：王丹

机构：[1]甘肃中医药大学中西医结合学院,兰州730000;[2]甘肃中医药大学附属医院脾胃病科,兰州730000;[3]甘肃省中心医院儿童急救中心二部,兰州730050

第一机构：甘肃中医药大学中西医结合学院

年份：2025

卷号：41

期号：12

起止页码：2615

中文期刊名：临床肝胆病杂志

外文期刊名：Journal of Clinical Hepatology

收录：;北大核心:【北大核心2023】；

基金：国家自然科学基金地区基金项目(81660773);2022年青年岐黄学者基金项目(国中医药人教函[2022]256号);甘肃省中医药管理局重点项目(GZKZ-2021-6);甘肃省科技厅重点研发计划(22YFTFA100);甘肃省科学技术厅创新基地和人才计划(21JR7RA682);中共甘肃省委组织部省级重点人才项目(2022RCXM020);甘肃省卫生行业科研计划项目(GSWSQN2022-01)。

语种：中文

中文关键词：代谢相关脂肪性肝病;线粒体;中医药疗法

外文关键词：Metabolic Associated Fatty Liver Disease;Mitochondria;Traditional Chinese Medicine Therapy

摘要：代谢相关脂肪性肝病(MAFLD)是一种与代谢紊乱有关的慢性肝病,其发病与肝细胞内脂肪大量堆积引起的脂毒性密切相关。近年研究表明,线粒体功能紊乱是MAFLD发病的重要机制,涉及线粒体氧化应激、线粒体自噬异常、线粒体凋亡异常和线粒体脂质代谢异常等一系列病理变化。中医药基于整体观念和辨证论治两大基本特点,在MAFLD的防治中发挥重要作用。本文对线粒体功能紊乱在MAFLD各病理过程中的作用及中医药的干预效应进行综述,以期从线粒体功能角度为中医药防治MAFLD提供新的思路与方法。
Metabolic associated fatty liver disease(MAFLD)is a chronic liver disease closely associated with metabolic disorders,and the onset of MAFLD is associated with lipotoxicity caused by the accumulation of a large amount of fat in hepatocytes.Recent studies have shown that mitochondrial dysfunction is an important mechanism for the development of MAFLD,involving a series of pathological changes including mitochondrial oxidative stress,abnormal mitochondrial autophagy,abnormal mitochondrial apoptosis,and abnormal mitochondrial lipid metabolism.Based on the two characteristics of holistic view and syndrome differentiation-based treatment,traditional Chinese medicine(TCM)plays an important role in the prevention and treatment of MAFLD.This article reviews the role of mitochondrial dysfunction in various pathological processes of MAFLD and the intervention effect of TCM,in order to provide new ideas and methods for TCM in the prevention and treatment of MAFLD from the perspective of mitochondrial function.