文献类型：期刊文献

英文题名：Gastrodin extends the lifespan and protects against neurodegeneration in the: Drosophila PINK1 model of Parkinson's disease

作者：He, Jianzheng[1,2]; Li, Xu[3]; Yang, Shipei[1]; Li, Yaling[1,2]; Lin, Xingyao[4]; Xiu, Minghui[3]; Li, Xuexiang[5]; Liu, Yongqi[1,4]

第一作者：何建政;和建政

通信作者：Liu, Yongqi|[1073525afe4b3ff1830b4]刘永琦;

机构：[1] Provincial-Level Key Laboratory for Molecular Medicine of Major Diseases, The Prev. and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and University, Gansu University of Chinese Medicine, Lanzhou, 730000, China; [2] College of Basic Medicine, Gansu University of Chinese Medicine, Lanzhou, 730000, China; [3] College of Public Health, Gansu University of Chinese Medicine, Lanzhou, 730000, China; [4] Key Laboratory for Transfer of Dunhuang Medicine at the Provincial and Ministerial Level, Gansu University of Traditional Chinese Medicine, Lanzhou, 730000, China; [5] College of Chemistry and Chemical Engineering, Northwestern Polytechnical University, Xi'an, 710072, China

第一机构：甘肃中医药大学

通信机构：[1]Provincial-Level Key Laboratory for Molecular Medicine of Major Diseases, The Prev. and Treatment with Traditional Chinese Medicine Research in Gansu Colleges and University, Gansu University of Chinese Medicine, Lanzhou, 730000, China;[3]College of Public Health, Gansu University of Chinese Medicine, Lanzhou, 730000, China|[10735]甘肃中医药大学;

年份：2021

卷号：12

期号：17

起止页码：7816

外文期刊名：Food and Function

收录：EI(收录号：20213610863342);Scopus(收录号：2-s2.0-85114206042)

语种：英文

外文关键词：Antioxidants - Neurons - Amines - Neurodegenerative diseases - Brain

摘要：Gastrodin is the main bioactive ingredient of a famous Chinese herb Rhizoma Gastrodiae. Many studies have reported that gastrodin has antioxidative and neuroprotective effects, although its effect on longevity and the mechanism of neuroprotection have not been well studied. Here, we use Drosophila melanogaster as a model to investigate the longevity and neuroprotective effects of gastrodin. Gastrodin significantly extended the lifespan, increased the climbing ability, enhanced the resistance to oxidative stress, increased the enzyme activities of superoxide dismutase (SOD) and catalase (CAT), and promoted the expression of anti-oxidative genes in old flies. The food intake, reproduction and starvation resistance were not affected in flies treated with gastrodin. Moreover, gastrodin delayed the onset of Parkinson-like phenotypes in Pink1B9 mutant flies, including the prolongation of the lifespan, rescue of the climbing ability, rescue of the progressive loss of a cluster of dopaminergic neurons in the protocerebral posterial lateral 1 region, and increase of the dopamine content in the brain. Gastrodin did not ameliorate the tau-induced neurobehavioral deficits in the fly AD model of taupathy. Together, these results indicate that gastrodin could prolong the lifespan by regulating the antioxidant ability, and protect against neurodegeneration in the Pink1B9 model of PD. This suggests that gastrodin can be considered as an ideal therapeutic candidate for drug development towards anti-aging. ? The Royal Society of Chemistry.