文献类型：期刊文献

中文题名：血清MMP-1、MMP-3、TIMP1及同型半胱氨酸水平在高血压并发心房颤动患者中的作用

英文题名：Role of serum MMP-1,MMP-3,TIMP-1 and Hcy levels in patients with hypertension complicated with atrial fibrillation

作者：陆玉琴[1];李应东[2];刘凯[2]

第一作者：陆玉琴

机构：[1]甘肃中医药大学附属医院心血管中心,甘肃兰州730020;[2]甘肃中医药大学,甘肃兰州730020

第一机构：甘肃中医药大学第二附属医院

年份：2020

卷号：35

期号：11

起止页码：976

中文期刊名：临床荟萃

外文期刊名：Clinical Focus

基金：甘肃省自然科学基金资助项目高血压病合并房颤患者MMPs、TIMP、hs-CRP、Hcy水平的研究(1508RJZA044)。

语种：中文

中文关键词：心房颤动;基质金属蛋白酶类;半胱氨酸

外文关键词：atrial fibrillation;matrix metalloproteinases;cysteine

摘要：目的探讨血清基质金属蛋白酶(MMP)1、MMP 3、基质金属蛋白酶抑制剂1(TIMP-1)、同型半胱氨酸(Hcy)水平在高血压合并心房颤动(房颤)患者中的作用。方法未经治疗或停药1周以上的高血压患者161例,根据心电图、动态心电图及病史分为窦性心律组及房颤组,检测所有患者血清MMP-1、MMP-3、TIMP-1水平、Hcy、尿酸(UA)、血脂水平,超声心动图测定左心房内径(LAD)。结果与窦性心律组相比,房颤组年龄、UA、Hcy、MMP-1/TIMP-1,MMP3/TIMP-1,LAD升高(P<0.05),而总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)明显降低(P<0.05);年龄、Hcy、LAD及MMP-1/TIMP-1是高血压患者发生房颤的独立危险因素。结论高龄、高Hcy、LAD增大及MMP-1/TIMP-1增高是高血压患者发生房颤的独立危险因素。
Objective To explore the role of serum matrix metalloproteinase(MMP)1,MMP 3,matrix metalloproteinase inhibitor 1(TIMP-1)and homocysteine(Hcy)levels in patients with hypertension complicated with atrial fibrillation(AF).Methods A total of 161 patients with hypertension who had not been treated or discontinued from medication for more than one week were divided into sinus rhythm group and atrial fibrillation group according to ECG,dynamic ECG and medical history.Serum MMP-1,MMP-3,TIMP-1,Hcy,uric acid(UA)and lipid levels were detected in all patients,and left atrial diameter(LAD)was determined by echocardiography.Results Compared with sinus rhythm group,the age,UA,Hcy,MMP-1/TIMP-1,MMP3/TIMP-1 and LAD of atrial fibrillation group were all increased(P<0.05),while the total cholesterol(TC)and low-density lipoprotein cholesterol(LDL-C)were significantly reduced(P<0.05).Age,Hcy,LAD and MMP-1/TIMP-1 were independent risk factors for atrial fibrillation in patients with hypertension.Conclusion Old age,high Hcy,enlarged LAD and increased MMP-1/TIMP-1 are independent risk factors for atrial fibrillation in patients with hypertension.