文献类型：期刊文献

中文题名：基于海马FXR调控CREB-BDNF信号通路影响抑郁症的研究进展

英文题名：Research progress on the effect of hippocampal FXR regulation of CREB-BDNF signaling pathway on depression

作者：何慧[1];郭明亮[1];冉立成[1];王亚军[1]

第一作者：何慧

机构：[1]甘肃中医药大学针灸推拿学院,甘肃兰州730000

第一机构：甘肃中医药大学针灸推拿学院

年份：2025

卷号：30

期号：2

起止页码：265

中文期刊名：中国临床药理学与治疗学

外文期刊名：Chinese Journal of Clinical Pharmacology and Therapeutics

收录：;北大核心:【北大核心2023】；

基金：国家自然科学基金(82160936)。

语种：中文

中文关键词：FXR;CREB-BDNF;信号通路;抑郁症

外文关键词：FXR;CREB-BDNF;signaling pathway;depression

摘要：抑郁症是一种以心境障碍为主要特征的精神类疾病,对人类的身心健康构成了重大的威胁。近年来,法尼醇X受体(farnesoid X receptor,FXR)已被发现在大脑海马体等脑区中表达,并与抑郁症的发病密切相关。其还可影响下游靶标环磷酸腺苷反应元件结合蛋白(cAMP response element binding protein,CREB)-脑源性神经营养因子(brain-derived-neurotrophic factor,BDNF)信号通路,有望作为治疗抑郁症的新靶点。本文分析海马FXR如何调控CREB-BDNF信号通路,并总结与抑郁症发病机制相关的最新研究进展,以期为抑郁症的药物研发和临床治疗提供精准靶向的思路。
Depression is a mental disorder characterized by mood disturbances that pose a significant threat to human mental and physical health.In recent years,the farnesoid X receptor(FXR)has been found to be expressed in brain regions such as the hippocampus and is closely related to the onset of depression.It can also affect the downstream target cAMP response element binding protein(CREB)-brain-derived neurotrophic factor(BDNF)signaling pathway,holding promise as a new target for the treatment of depression.This article analyzes how hippocampal FXR regulates the CREB-BDNF signaling pathway and summarizes the latest research progress related to the pathogenesis of depression,with the aim of providing precise targeted ideas for the drug development and clinical treatment of depression.