文献类型：期刊文献

英文题名：Programmed cell death in osteoarthritis

作者：Li, Haolin[1];Chen, Ping[2];Cheng, Weigang[1];Zhang, Zhimin[1];Yang, Juanjuan[3];Zhang, Hao[3];Jin, Fangmei[3];Kan, Lili[3];Chen, Lei[1];Wang, Haidong[1]

第一作者：李海龙

通信作者：Chen, L[1];Wang, HD[1]

机构：[1]Gansu Univ Tradit Chinese Med, Coll Tradit Chinese Med, Lanzhou, Peoples R China;[2]Gansu Prov Hosp Tradit Chinese Med, Hlth Management Ctr, Lanzhou, Peoples R China;[3]Gansu Prov Hosp Tradit Chinese Med, Rheumatism & Bone Dis Ctr, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Coll Tradit Chinese Med, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2026

卷号：31

期号：1

外文期刊名：APOPTOSIS

收录：;Scopus(收录号：2-s2.0-105026935699);WOS:【SCI-EXPANDED(收录号:WOS:001660256100003)】；

基金：The study was supported by grants from the National Natural Science Foundation of China (82460945 and 82260880 to CP ), Gansu Province Traditional Chinese Medicine Project (High-Level Key Project) (GZKZ-2024-4 to CP), Zhouqu County 2024 Science and Technology Plan Project (Zhouke Zi [2024] No. 45 to WHD), Lanzhou Municipal Science and Technology Bureau Project (2024-9-41 to JFM), Longyuan Young Talent Cultivation Programme (Document No. 11 [2024] issued by the Provincial Party Committee Talent Development Group to CP).

语种：英文

外文关键词：Osteoarthritis; Programmed cell death; Molecular mechanisms; Review

摘要：Osteoarthritis (OA) is a prevalent degenerative joint disease with complex and multifactorial etiology, primarily affecting elderly populations. Factors such as mechanical stress and aging contribute to cartilage degeneration and joint damage. OA manifests through extracellular matrix (ECM) degradation in chondrocytes, decreased chondrocyte viability, and is associated with significant incidence and disability. Recent research indicates that multiple patterns of programmed cell death (PCD), including apoptosis, pyroptosis, necroptosis, autophagy, ferroptosis, cuproptosis, and PANoptosis, regulate the survival and death of chondrocytes through intricate molecular networks, thereby contributing to the onset and progression of OA.This review elucidates the molecular underpinnings of these seven forms of PCD and emphasizes their significance in OA pathology, with a view to providing new perspectives for in-depth research into the pathogenesis of OA and the development of targeted drugs.