文献类型：期刊文献

中文题名：铁死亡在代谢相关脂肪性肝病中的作用研究进展

英文题名：Research progress on the role of ferroptosis in metabolic associated fatty liver disease

作者：余臣祖[1];张朝宁[2];张燕[3]

第一作者：余臣祖

机构：[1]甘肃中医药大学第一临床医学院,甘肃兰州730000;[2]甘肃中医药大学中医临床学院,甘肃兰州730000;[3]兰州大学第二医院体检中心,甘肃兰州730030

第一机构：甘肃中医药大学临床医学院

年份：2023

卷号：8

期号：32

起止页码：191

中文期刊名：临床医学研究与实践

外文期刊名：Clinical Research and Practice

基金：甘肃省自然科学基金(No.21JR7RA567)。

语种：中文

中文关键词：代谢相关脂肪性肝病;铁死亡;非酒精性脂肪性肝炎

外文关键词：metabolic associated fatty liver disease;ferroptosis;nonalcoholic steatohepatitis

摘要：代谢相关脂肪性肝病(MAFLD)又名非酒精性脂肪肝病(NAFLD),是一组常见慢性肝病的总称,包括非酒精性单纯性脂肪肝(NAFL)、非酒精性脂肪性肝炎(NASH)、肝纤维化、肝硬化及肝癌。铁死亡是一种因铁过载导致毒性脂质过氧化物累积进而驱动的新型细胞死亡方式。近年来的大量研究显示铁死亡参与MAFLD的发生及NASH病情进展,抑制铁死亡将在MAFLD病情进展中发挥重要的治疗作用,可能成为治疗MAFLD的新靶点。本文将介绍铁死亡在MAFLD中的最新研究进展及其潜在的作用机制,为临床治疗提供参考。
Metabolic associated fatty liver disease(MAFLD),also known as nonalcoholic fatty liver disease(NAFLD),is a general term for a group of common chronic liver diseases,and it includes nonalcoholic simple fatty liver(NAFL),nonalcoholic steatohepatitis(NASH),liver fibrosis,cirrhosis and liver cancer.Ferroptosis is a new type of cell death driven by the accumulation of toxic lipid peroxides caused by iron overload.In recent years,a large number of studies have shown that ferroptosis is involved in the occurrence of MAFLD and the progression of NASH.Inhibition of ferroptosis will play an important therapeutic role in the progression of MAFLD and may become a new target for the treatment of MAFLD.This article will introduce the latest research progress of ferroptosis in MAFLD and its potential mechanism,so as to provide reference for clinical treatment.