文献类型：期刊文献

中文题名：安神二号胶囊联合盐酸文拉法辛缓释片对焦虑障碍患者认知、社会功能的影响

英文题名：Effects of AnShen Capsule No.2 and Venlafaxine Hydrochloride Sustained-release Tablets on Cognition and Social Function of Patients with Anxiety Disorder

作者：石洲宝[1];刘敏科[1];黄生辉[1];唐珂[1];高丽波[1]

第一作者：石洲宝

机构：[1]甘肃中医学院附属医院脑病科,甘肃兰州730020

第一机构：甘肃中医药大学第二附属医院

年份：2013

卷号：26

期号：4

起止页码：4

中文期刊名：西部中医药

外文期刊名：Western Journal of Traditional Chinese Medicine

收录：CSTPCD

语种：中文

中文关键词：焦虑障碍;认知及社会功能;安神二号胶囊;盐酸文拉法辛缓释片

外文关键词：anxiety disorder; cognition and social function; A nShen capsule No.2; venlafaxine hydrochloridesustained-release tablets

摘要：目的:探讨安神二号胶囊与盐酸文拉法辛对焦虑障碍认知及社会功能的影响。方法:将180例符合DSM-Ⅳ标准的焦虑障碍患者随机分为治疗组和对照组各90例,观察时间均为8周。以HAMA、HAMD、WCST及社会功能SDSS作为疗效评价工具。结果:治疗第8周末,2组HAMA、HAMD及社会功能SDSS评分均较基线降低,WCST指标中,除了治疗组持续应答数外均获改善,差异均有统计学意义(P<0.01);治疗组HAMA、HAMD评分的降低较对照组更为明显。与基线比较,治疗组WCST分类数较基线治疗组增加(-1.0±1.5),对照组增加(-0.4±1.1);正确应答数治疗组增加(-10.1±15.4),对照组增加(-5.0±16.3);错误应答数治疗组降低(15.1±25.5),对照组降低(7.0±23.3);概念化水平百分数治疗组增加(-14.9±22.8),对照组增加(-9.2±26.3)。SDSS评分较基线治疗组降低(6.1±4.3)分,对照组降低(4.5±3.6)分。组间上述各项比较,差异均有统计学意义(P<0.05)。结论:安神二号胶囊配合盐酸文拉法辛治疗,对焦虑障碍患者的焦虑障碍、认知及社会功能的改善更为有效。
Objective： To evaluate the effects ofA nShen capsule No.2 combined with venlafaxine hydrochloride sustained-release tablets on cognition and social function of patients with anxiety disorder. Method： All 180 patients, who met the standard of DSM-IV, were randomly divided into the treatment group and the control group, the observation time was eight weeks. Hamilton anxiety （HAMA）, Hamilton depression scale （HAMD）, Wisconsin card sorting test （WCST） and social disability screening schedule （SDSS） were taken as the tools to assess clinical effects.Result： By the end of 8th week, HAMA, HAMD and SDSS of both groups were lower than the baseline and the difference showed statistical meanings in improvements of WCST indexes except the numbers of persistent responses in the treatment group （P〈0.01）; the decrease of the treatment group was more significant than that of the control group in the score of HAMA and HAMD. Compared with the baseline, WSCT of the treatment group increased （-1.0±1.5）, and the control group increased （-0.4±1.1）; correct responses of the treatment group increased （-10.1 ±15.4）, and the control group raised （-5.0±16.3）; wrong responses of the treatment group declined （15.1 ±25.5） and the control group lowered （7.0±23.3）; the conceptual level of the treatment group increased （-14.9±22.8）, the control group raised （-9.2±26.3）. The scale of SDSS in the treatment group decreased （6.1 ±4.3） and the control group lowered （4.5±3.6）. Comparisons between both groups had differences and they showed statistical meaning （P〈0.05）. Conclusion： AnShen capsule No.2 combined with Venlafaxine hydrochloride sustained-release tablets are effective in improving anxiety disorder, cognition and social function in patients.