文献类型：期刊文献

中文题名：中药单体调控成骨-血管耦合机制治疗骨质疏松症的研究现状

英文题名：Current research on the mechanisms by which chinese medicinal monomer regulate osteogenesis-angiogenesis coupling in the treatment of osteoporosis

作者：路虎[1];陈欣[2];陈一新[3];安文博[2];齐伟[2];陈诺[1];李慧[1];刘建军[2]

第一作者：路虎

机构：[1]甘肃中医药大学中医临床学院,甘肃兰州730000;[2]甘肃中医药大学附属医院骨伤中心,甘肃兰州730020;[3]兰州市第一人民医院骨科,甘肃兰州730050

第一机构：甘肃中医药大学中医临床学院

年份：2026

卷号：42

期号：3

起止页码：419

中文期刊名：中国临床药理学杂志

外文期刊名：The Chinese Journal of Clinical Pharmacology

收录：;北大核心:【北大核心2023】；

基金：2024年甘肃省自然科学基金资助项目(24JRRA1034);2024年校(院)企联合基金资助项目(HXLH-JBGS04);2024年甘肃省卫生健康行业重大科研基金资助项目(GSWSZD2024-19);2021兰州市科技局指导性计划基金资助项目(2022-ZD-91)。

语种：中文

中文关键词：中药单体;骨质疏松症;成骨;血管生成;耦合机制

外文关键词：Chinese medicinal monomer;osteoporosis;osteogenesis;angiogenesis;coupling mechanism

摘要：骨质疏松症(OP)是一种严重的危害人类身心健康的骨骼系统疾病,主要的病理特点是骨密度降低、骨组织质量下降、骨微结构破损、骨力学强度减弱。导致OP的发病机理涉及成骨细胞、破骨细胞间通讯功能障碍、骨重塑稳态失调;血管生成障碍、慢性炎症反应、氧化应激损伤等多方面。值得注意的是,在骨组织生成、OP发生发展以及骨折愈合的过程中,始终存在着血管生成与骨形成之间的关联,是调控骨代谢的关键环节。近年来,中医药(TCM)在防治OP方面表现出显著的优势及确切疗效,临床中应用较多的单体中药通过多途径、多靶点促进成骨细胞增殖分化,并且能够提高成骨血管生成的能力,改善骨组织血供,进而使得骨密度得以提升,对预防和治疗OP均有十分重要的意义。本文系统综述近年来中药单体治疗OP的研究进展,旨在为TCM防治该病探索新的诊疗思路与实践路径。
Osteoporosis(OP)is a severe skeletal system disease that endangers human physical and mental health,characterized primarily by decreased bone mineral density,impaired bone tissue quality,disrupted bone microstructure and reduced bone mechanical strength.The pathogenesis of OP involves multiple aspects,including impaired communication between osteoblasts and osteoclasts,dysregulated bone remodeling homeostasis,as well as angiogenesis disorders,chronic inflammatory responses and oxidative stress damage.Notably,the correlation between angiogenesis and osteogenesis exists throughout bone formation,the development and progression of OP,and fracture healing,serving as a key link in the regulation of bone metabolism.In recent years,traditional Chinese medicine(TCM)has demonstrated remarkable advantages and definite curative effects in the prevention and treatment of OP.Commonly used Chinese medicinal monomer in clinical practice can promote the proliferation and differentiation of osteoblasts through multiple pathways and targets,enhance the angiogenic capacity of osteogenic tissue,improve blood supply to bone tissue,and thereby increase bone mineral density,which is of great significance for the prevention and treatment of OP.This paper systematically reviews the recent research progress on Chinese medicinal monomer in the treatment of OP,aiming to explore new diagnostic and therapeutic ideas and practical approaches for the prevention and treatment of this disease with TCM.