文献类型：期刊文献

英文题名：Biological mechanism of ZnO nanomaterials

作者：Li, Yuanyuan[1];Li, Jingjing[2];Li, Mei[1];Sun, Jiwen[1];Shang, Xiaofen[1];Ma, Yonghua[1,3]

第一作者：Li, Yuanyuan

通信作者：Ma, YH[1]

机构：[1]Gansu Agr Univ, Coll Vet Med, Lanzhou, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Coll Pharm, Lanzhou, Peoples R China;[3]Gansu Agr Univ, Coll Vet Med, Lanzhou 730070, Peoples R China

第一机构：Gansu Agr Univ, Coll Vet Med, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Gansu Agr Univ, Coll Vet Med, Lanzhou 730070, Peoples R China.

年份：2024

卷号：44

期号：1

起止页码：107

外文期刊名：JOURNAL OF APPLIED TOXICOLOGY

收录：;Scopus(收录号：2-s2.0-85166418044);WOS:【SCI-EXPANDED(收录号:WOS:001039404300001)】；

基金：Lanzhou Science and Technology Plan Project,Grant/Award Number: 2022-2-112; Gansu Agricultural University, Grant/Award Numbers:GAU-XKJS-2018-073, GAU-KYQD-2017RCZX-11, GAU-QDFC-2020-11; Gansu Province Natural Sciences Fund, Grant/AwardNumbers: 18JR3RA16, 21JR1RA233; National Natural Science Foundation Project (CN),Grant/Award Number: 31460659

语种：英文

外文关键词：antibacterial; antiviral; eukaryotic cell; reactive oxygen species; zinc oxide nanomaterials

摘要：Modern nanotechnology has made zinc oxide nanomaterials (ZnO NMts) multifunctional, stable, and low cost, enabling them to be widely used in commercial and biomedical fields. With its wide application, the risk of human direct contact and their release into the environment also increases. This review aims to summarize the toxicity studies of ZnO NMts in vivo, including neurotoxicity, inhalation toxicity, and reproductive toxicity. The antibacterial and antiviral mechanisms of ZnO NMts in vitro and the toxicity to eukaryotic cells were summarized. The summary found that it was mainly related to reactive oxygen species (ROS) produced by oxidative stress. It also discusses the potential harm to body and the favorable prospects of the widespread use of antibacterial and antiviral in the future medical field. The review also emphasizes that the dosage and use method of ZnO NMts will be the focus of future biomedical research.