文献类型：期刊文献

中文题名：Preparation and MRI performances of core-shell structural PEG salicylic acid-gadolinium composite nanoparticles

作者：Jia Zhang[1];Zhiyan Lin[2];Minzhi Zhao[1];Weibing Xu[1];Fang Nian[1]

第一作者：Jia Zhang

机构：[1]College of Science,Gansu Agricultural University,Lanzhou 730000,China;[2]Clinical Medical College,Gansu University of Chinese Medicine,Lanzhou 730000,China

第一机构：College of Science,Gansu Agricultural University,Lanzhou 730000,China

年份：2022

卷号：40

期号：7

起止页码：1098

中文期刊名：Journal of Rare Earths

外文期刊名：稀土学报（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2021_2022】；

基金：Project supported by the Natural Science Foundation of Gansu Province(20JR10RA511,2019B-084)。

语种：英文

中文关键词：Gadolinium;Salicylic acid;Polyethylene glycols;Core-shell structural;MRI contrast agent;Rare earths

摘要：Gadolinium(Ⅲ)-based T_(1) contrast agents have been widely used in clinical MRI.In this study,salicylic acid-gadolinium chelate was prepared via directly coordination reaction of gadolinium ion and salicylic acid.Then,three polyethylene glycols with different molecular weight were modified on the surface of salicylic acid-gadolinium by simple chemical coupling to construct three core-shell structural Gd based composites.The scanning electron microscopy(SEM)and transmission electron microscopy(TEM)characterization results show that the composite is a spherical particle with a diameter of about 100-200 nm.The longitudinal relaxation rate r_(1) of the Gal-PEG-2000 is 11.097(mmol/L)^(-1)/s,and the ratio of r_(2)/r_(1) is as low as 2.53.The composite shows good liver and intestines MRI performances after being used in in vivo imaging,showing a good prospect of biological application.