文献类型：期刊文献

中文题名：Salvianolic acids improve liver lipid metabolism in ovariectomized rats via blocking STAT-3/SREBP1 signaling

英文题名：Salvianolic acids improve liver lipid metabolism in ovariectomized rats via blocking STAT-3/SREBP1 signaling

作者：Chen Juan[1];Yue Jia[2];Liu Jiao[1];Liu Yun[1];Mao Kai-Lin[1];Teng Meng-Ying[1];Hu Chun-Yan[1];Zhen Jing[1];Wu Mao-Xuan[1];Zhou Ming[1];Li Zhong[1];Li Yuan[1]

第一作者：Chen Juan

通信作者：Li, Z[1];Li, Y[1]

机构：[1]Nanjing Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Nanjing 211166, Jiangsu, Peoples R China;[2]Gansu Univ Chinese Med, Sch Publ Hlth, Dept Nutr & Food Hyg, Lanzhou 730000, Gansu, Peoples R China

第一机构：Nanjing Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Nanjing 211166, Jiangsu, Peoples R China

通信机构：[1]corresponding author), Nanjing Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Nanjing 211166, Jiangsu, Peoples R China.

年份：2018

卷号：16

期号：11

起止页码：838

中文期刊名：中国天然药物：英文版

外文期刊名：CHINESE JOURNAL OF NATURAL MEDICINES

收录：CSTPCD;;Scopus(收录号：2-s2.0-85057247284);WOS:【SCI-EXPANDED(收录号:WOS:000451451700004)】；CSCD:【CSCD2017_2018】；PubMed;

基金：This work was supported by National Natural Science Foundation of China (Nos. 81573183 and 81673205), the Major Program of Natural Science Research of Jiangsu Higher Education Institutions (No. 15KJA330001), the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), Gansu Provincial Natural Science Foundation (No. 148RJZA081), and Lanzhou Science and Technology (2014-1-18).

语种：英文

中文关键词：Salvianolic 酸；类脂化合物新陈代谢；重量获得；表明抄写 3 的变换器和使活跃之物

外文关键词：Salvianolic acids; Lipid metabolism; Weight gain; Signal transducer and activator of transcription 3

摘要：Postmenopausal women, who have reduced circulating estrogen levels, are more prone to develop obesity and related metabolic diseases than premenopausal women. The absence of safe and effective treatments for postmenopausal obesity has changed the focus to natural products as alternative remedies. Total salvianolic acids(TSA) are the major water-soluble ingredients of Danshen. Salvianolic acid(SA) is the major constituent of the TSA. Salvianolic acids, including TSA and SA, are widely used in traditional Chinese medicine. In the present study, ovariectomized rats and LO2 cells were used to study the effects of salvianolic acids on body weight gain and hepatic steatosis. Salvianolic acids reduced ovariectomy(OVX)-induced body weight gain, attenuated the expressions of hepatic lipogenic genes, such as sterol regulatory element binding protein(SREBP)1, fatty acid synthase(FAS), and stearoyl-CoA desaturase(SCD)1, and decreased the liver triglyceride(TG) and total cholesterol(TC). For the molecular mechanisms, OVX and high glucose-induced phosphorylation of signal transducer and activator of transcription(STAT)-3 was inhibited by salvianolic acids treatment. In LO2 cells, inhibition of STAT-3 by siRNA attenuated the increased expression of SREBP1 and TG induced by high glucose. Salvianolic acids reduced the upregulation of SREBP1 and TG induced by high glucose in LO2 cells. In conclusion, these findings illustrated that salvianolic acids markedly alleviated the lipid metabolism disorders and protected against the postmenopausal obesity. The underlying mechanism was probably associated with the regulation of STAT-3 signaling.
Postmenopausal women, who have reduced circulating estrogen levels, are more prone to develop obesity and related metabolic diseases than premenopausal women. The absence of safe and effective treatments for postmenopausal obesity has changed the focus to natural products as alternative remedies. Total salvianolic acids (TSA) are the major water-soluble ingredients of Danshen. Salvianolic acid (SA) is the major constituent of the TSA. Salvianolic acids, including TSA and SA, are widely used in traditional Chinese medicine. In the present study, ovariectomized rats and LO2 cells were used to study the effects of salvianolic acids on body weight gain and hepatic steatosis. Salvianolic acids reduced ovariectomy (OVX)-induced body weight gain, attenuated the expressions of hepatic lipogenic genes, such as sterol regulatory element binding protein (SREBP) 1, fatty acid synthase (FAS), and stearoyl-CoA desaturase (SCD)1, and decreased the liver triglyceride (TG) and total cholesterol (TC). For the molecular mechanisms, OVX and high glucose-induced phosphorylation of signal transducer and activator of transcription (STAT)-3 was inhibited by salvianolic acids treatment. In LO2 cells, inhibition of STAT-3 by siRNA attenuated the increased expression of SREBP1 and TG induced by high glucose. Salvianolic acids reduced the upregulation of SREBP1 and TG induced by high glucose in LO2 cells. In conclusion, these findings illustrated that salvianolic acids markedly alleviated the lipid metabolism disorders and protected against the postmenopausal obesity. The underlying mechanism was probably associated with the regulation of STAT-3 signaling.